Description
Annual Reports in Medicinal Chemistry
Director of collection: Desai Manoj C
Language: EnglishSubject for Annual Reports in Medicinal Chemistry:
Keywords
Acotiamide; Ado-trastuzumab emtansine; Afatinib; Antivirals; Canagliflozin; Cetilistat; Cobicistat; Dabrafenib; Dengue virus; Dimethyl fumarate; Dolutegravir; Efinaconazole; Elvitegravir; HBV; HCV; HIV; Ibrutinib; Istradefylline; Lixisenatide; Macitentan; Metreleptin; Mipomersen; Nucleosides; Nucleotides; Obinutuzumab; Olodaterol; Ospemifene; Pomalidomide; Prodrugs; Saroglitazar; Simeprevir; Sofosbuvir; Trametinib; Vortioxetine
636 p. · 15x22.8 cm · Paperback
Description
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/li>Biography
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- A Personal Essay: My Experiences in the Pharmaceutical Industry
- Adventures in Medicinal Chemistry - A Career in Drug Discovery
- Natural and Synthetic Neuroactive Steroid (NAS) Modulators of GABAA and NMDA Receptors
- Development of LRRK2 Kinase Inhibitors for Parkinson’s Disease
- Stimulating Neurotrophin Receptors in the Treatment of Neurodegenerative Disorders
- Small Molecule Modulators of GPR40 (FFA1)
- Recent Advances in the Development of P2Y12 Receptor Antagonists as Antiplatelet Agents
- Current Approaches to the Treatment of Atrial Fibrillation
- Advances in the Discovery of Small Molecule IRAK4 Inhibitors
- H4 Receptor Antagonists and Their Potential Therapeutic Applications
- Urate Crystal Deposition Disease and Gout - New Therapies for an Old Problem
- p53 - MDM2 and MDMX Antagonists
- Modulators of Atypical Protein Kinase C as Anticancer Agents
- Advancement of Cell Wall Inhibitors in Mycobacterium Tuberculosis
- Nucleosides and Nucleotides for the Treatment of Viral Diseases
- Advances in Inhibitors of Penicillin Binding Proteins and ß-lactamases as Antibacterial Agents
- Tumor Microenvironment as Target in Cancer Therapy
- Novel Screening Paradigms for the Identification of Allosteric Modulators and /or Biased Ligands for Challenging G-Protein-Coupled Receptors (GPCRs)
- Mer Tyrosine Kinase Receptor: Therapeutic Opportunities in Oncology, Virology and Cardiovascular Indications
- Disease Modifying Agents for the Treatment of Cystic Fibrosis
- Advancements in Stapled Peptide Drug Discovery and Development
- Cytochrome P450 Enzyme Metabolites in Lead Discovery and Development
- Case History: ForxigaTM (Dapagliflozin), a Potent Selective SGLT2 Inhibitor for Treatment of Diabetes
- Case History: Kalydeco® (VX-770, Ivacaftor), a CFTR Potentiator for the Treatment of Patients with Cystic Fibrosis and the G551D-CFTR Mutation
- Case History: XeljanzTM (Tofacitinib Citrate), A First-In-Class Janus Kinase (JAK) Inhibitor for the Treatment of Rheumatoid Arthritis
- New Chemical Entities Entering Phase III Trials in 2013
- To Market, To Market – 2013
Ideally suited for chemists engaged in multidisciplinary teams for drug discovery; this includes medicinal chemists and others involved in chemical biology and bio-organic disciplines and computational chemistry
Dr. Manoj Desai began his career in the pharmaceutical industry at Pfizer Inc, Central Research Division, Groton, CT (1986-1994) before moving to Chiron Corporation (1994-2003) as Director of medicinal chemistry; he was promoted to Vice President, lead discovery and medicinal chemistry (2000). In October 2003, he was appointed Vice President of medicinal chemistry at Gilead Sciences. At Pfizer, he was responsible for the medicinal chemistry efforts that lead to the discovery of oral Substance P antagonist CP-99994 which became the basis for the discovery of the new anti-emetics. At Chiron he formulated macrobead technology for the synthesis and screening of compound libraries for HTS and built the medicinal chemistry department with focus on kinase inhibitors. At Gilead, he was an active proponent to develop a pharmacoenhancer devoid of antiviral activity to improve the pharmacokinetics of integrase inhibitor elvitegravir. These efforts led to the discovery of Cobicistat which is one of components of StribildTM that was approved by FDA in August 2012 for the treatment of HIV infection. He is co-inventor on patents of Cobicistat (US 8,148,374), StribildTM and Ledipasvir (US 8,273,341; Phase III). Furthermore, his group at Gilead has advanced numerous compounds into clinical development for the treatment of antiviral diseases, cancer and cardiovascular diseases.
Dr. Desai obtained Ph.D. in organic chemistry from the M.S. University of Baroda in 1981 working with Dr. Sukh Dev and then carried out post-doctoral fellowships at Purdue University working with Professor Herbert C. Brown (19981-1983) and at Harvard University with Professor Elias J. Corey (1983-1986). During his postdoctoral studies, he worked on natural product isolation, development of asymmetric synthetic methods using organoboranes and total synthesis of complex natural products such as retigeranic acid, ?-trans bergamotene and ginkgolide B.
He has co-authored >60 publications in peer rev
- Reviews on hot topics of interest in small molecule drug discovery heavily pursued by industrial research organizations
- Provides preclinical information in the context of chemical structures
- Knowledgeable section editors who evaluate invited reviews for scientific rigor