Anxiety Disorders, 2002
Pathophysiology and Pharmacological Treatment

In this book, the discussion of the normal and pathological aspects of anxiety is critically examined. A chapter on the molecular basis of anxiety is included, outlining the potential of such approach in the discovery of novel effective pharmacological interventions. The face validity, predictability and usefulness of animal models in the design of valid new efficacious products are discussed. Separate chapters dedicated to each particular type of anxiety such as generalized anxiety disorder, social phobia, posttraumatic stress disorder, panic and obsessive-compulive disorder are included. This book should be of benefit to psychiatrists, clinical psychologists, general practitioners, nurses, students and all those engaged in neuropsychiatric research.

1:Normal and pathological anxiety.- 1 What is anxiety?.- 2 Relevance of laboratory research on anxiety disorders.- 3 Genetic factors and brain imaging.- 4 Management.- 5 Discussion.- 2:Biological basis of anxiety and strategies for pharmacological innovation.- 1 Introduction.- 2 Neurobiology of anxiety disorders.- 3 Recent development and future anxiolytics.- 4 Discussion.- 3:Generalised anxiety disorder.- 1 Introduction.- 2 Diagnostic.- 3 The phenomenon of worry.- 4 Neurobiology.- 5 Physiopathology.- 6 Epidemiology and natural course.- 7 Treatment.- 8 Methodology for clinical investigation.- 9 Discussion.- 4:Social phobia.- 1 Introduction.- 2 Diagnosis and comorbidity.- 3 Pathophysiology.- 4 Treatments.- 5 Methodology of clinical investigations.- 6 Discussion.- 5:Panic disorder.- 1 Introduction.- 2 Diagnosis and aetiology.- 3 Pathophysiology.- 4 Treatments.- 5 Methodology for clinical investigation.- 6 Discussion.- 6:Obsessive-compulsive disorder.- 1 Introduction.- 2 Diagnostic.- 3 Physiopathology.- 4 Treatment.- 5 Methodology for clinical investigation.- 6 Discussion.- 7:Posttraumatic stress disorder.- 1 Introduction.- 2 Epidemiology.- 3 Comorbidity.- 4 Physiological and neurological abnormalities associated with PTSD.- 5 Cognitive dysfunction associated with PTSD.- 6 Treatment of PTSD.- 7 Discussion.- 8:Phobic disorders.- 1 Introduction.- 2 Epidemiology.- 3 Genetics.- 4 Treatment.- 5 Discussion.- 9:Laboratory models of anxiety.- 1 Introduction.- 2 Biological animal models.- 3 Behavioural animal models.- 4 Human models.- 5 Issues relevant to some non-benzodiazepine anxiolytics.- 6 Discussion.- 10:Discussion and perspectives.- Future perspectives.