Autonomic and Enteric Ganglia, Softcover reprint of the original 1st ed. 1986 Transmission and Its Pharmacology

In the early 1960s, Dr. Alexander G. Karczmar, Professor of Pharmacology and Experimental Therapeutics at the Stritch School of Medicine of the Medical Center at Loyola University of Chicago, was confronted with a certain technical problem concerning his studies of synaptic transmission by means of microelectrode methods. He thought that the problem might be resolved if he could interest a microelectrode expert such as Dr. Kyozo Koketsu in his studies. Dr. Koketsu was a past member of the Faculty of the Kurume University School of Medicine who as a Research Fellow at the Australian National University had helped Sir John Eccles, subse­ quently a Nobel Prize winner, in developing microelectrode procedures. After further considering the matter, Dr. Karczmar was pleasantly sur­ prised to discover that by coincidence Dr. Koketsu was his neighbor, serving at that time as a Research Professor at the Neuropsychiatry Institute of the University of Illinois, College of Medicine of Chicago. This was the beginning of a long relationship, as Dr. Koketsu joined Dr. Karczmar at Loyola as Professor of Pharmacology and Therapeutics and Director of the Neurophysiology Laboratory at the Stritch School of Medicine. It was not long before Dr. Syogoro Nishi-Dr. Koketsu's former colleague on the Faculty of Medicine at Kurume University, and at that time a Research Fellow in Neurophysiology at the Rockefeller Institute in New York­ joined Drs. Koketsu and Karczmar at Loyola. Although in due time Drs.

I. History and Anatomical Bases of Ganglionic and Enteric Transmission.- 1. Historical Development of Concepts of Ganglionic Transmission.- 2. Anatomy, Histology, and Electron Microscopy of Sympathetic, Parasympathetic, and Enteric Neurons.- II. Transmission and Modulation in Sympathetic Ganglia and Their Neuropharmacology.- 3. General Concepts of Ganglionic Transmission and Modulation.- 4. Electrophysiological Properties of Sympathetic Neurons.- 5. General Characteristics and Mechanisms of Nicotinic Transmission in Sympathetic Ganglia.- 6. Nicotinic Receptors: Activation and Block.- 7. Muscarinic Transmission.- 8. Peptidergic Transmission.- 9. Inhibitory Transmission: Slow Inhibitory Postsynaptic Potential.- 10. Presynaptic Modulation: The Mechanism and Regulation of Transmitter Liberation in Sympathetic Ganglia.- 11. Presynaptic Modulation: Endogenous Substances with Ganglionic Depressant Actions.- 12. Postsynaptic Modulation.- 13. Pharmacology of Synaptic Ganglionic Transmission and Second Messengers.- III. Parasympathetic and Enteric Ganglia and Their Neuropharmacology.- 14. Excitatory Transmission in Parasympathetic Ganglia.- 15. Inhibition in Parasympathetic Ganglia.- 16. Transmission in Enteric Ganglia.- IV. Spinal and Reflex Activities of the Ganglia.- 17. The Pharmacology of Sympathetic Preganglionic Neurons.- 18. Spontaneous and Reflex Activities: General Characteristics.- 19. Chemosensitivity of Visceral Primary Afferent Neurons: Nodose Ganglia.- V. Clinical and CNS-Related Aspects of Ganglionic Transmission.- 20. Autonomic Disease and Clinical Applications of Ganglionic Agents.- 21. Ganglionic Transmission as a Model for CNS Function.