Description
Biomolecular Action of Ionizing Radiation
Series in Medical Physics and Biomedical Engineering Series
Author: Lehnert Shirley
Language: EnglishSubjects for Biomolecular Action of Ionizing Radiation:
Keywords
DNA Damage; transcription; DNA Repair; factor; DNA Molecule; mammalian; DNA Damage Response; cells; DNA End; non-homologous; Pe Rc; end; Single Strand DNA; joining; Be; cell; Protein Kinase; cycle; DNA Double Helix; arrest; PCC; DNA Double Strand Break; DNA Polymerase; DNA Ligase Iv; DNA DSB; Radiation Induce DNA Strand Break; Radiation Induced Genomic Instability; DNA Loop; Atm Kinase Activity; Radiation Induced Bystander Effects; Nonirradiated Cells; Atm Protein; PI3K Pathway; DNA Pk Complex; Ionizing Radiation
Publication date: 04-2018
· 15.6x23.4 cm · Hardback
Publication date: 10-2007
372 p. · 15.6x23.4 cm · Hardback
Description
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Embracing the transformation of radiation sciences by the recent surge of developments in molecular biology, this progressive text offers an up-to-date analysis of in vitro and in vivo molecular responses in the body induced by ionizing radiation. With a unique emphasis on medical physics applications, Biomolecular Action of Ionizing Radiation also presents a much needed, in-depth perspective on clinical applications for the treatment of cancer and radiation injuries.
Based on a popular course given by the author at McGill University,the bookplaces the traditional tenets of radiation biology in the context of contemporary cell and molecular biology. Using terms that non-experts in molecular biology can understand, it clarifies the underlying mechanisms of radiation effects on molecular interactions including signal transduction pathways, modes of cell killing, and non-targeted effects. The author subsequently associates key principles and advances with potential applications, including the use of ionizing radiation as a cytotoxic and cytostatic agent, and radiosensitization by targeting molecular intermediates or signaling molecules involved in radiation-induced processes.
Raising the standard for radiation biology texts that are currently available, Biomolecular Action of Ionizing Radiation is an outstanding resource for advanced undergraduate and graduate students in medical physics, radiation oncology, radiation biology, and those who have an interest in the radiation sciences and in cancer treatment.