Brain Lipids in Synaptic Function and Neurological Disease Clues to Innovative Therapeutic Strategies for Brain Disorders
Auteurs : Fantini Jacques, Yahi Nouara
Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer?s, Creutzfeldt-Jakob?s and Parkinson?s. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders.
Part I. Brain Lipids1. Chemical basis of lipid biochemistry2. Brain membranes3. Lipid metabolism and oxidation in neurons and glial cells4. Variations of brain lipid content
Part II. Brain Lipids and Synaptic Functions5. A molecular view of the synapse6. Protein-lipid interactions in the brain7. Lipid regulation of receptor function
Part III. Brain Lipids and Neurodegenerative Disease8. Common mechanisms in neurodegenerative diseases9. Creutzfeldt-Jakob’s disease10. Parkinson’s disease11. Alzheimer’s disease
Part IV. Brain Pathogens and Amyloidogenic Proteins: The Lipid Connection12. Viral and bacterial diseases13. A unifying theory14. Therapeutic strategies for neurodegenerative diseases
Neuroscience graduate students, post-doctoral fellows, experienced researchers new to neuroscience, and senior researchers that want technique updates
Nouara Yahi was born in France in 1964. She has accumulated 25 years of fundamental research and teaching experience in virology and molecular biology areas. She has been a pioneer in the analysis of resistance mutations in patients with HIV infections, and has published several important articles in this field. She is currently professor of biochemistry at Aix-Marseille University and leader of the research group ‘Molecular Interactions in Model and Biological Membrane Systems’. This gr
- Written to provide a "hands-on" approach for readers
- Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings
- Step-by-step guide to memorize and draw lipid structures
- Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique
Date de parution : 07-2015
Ouvrage de 398 p.
19x23.3 cm
Thème de Brain Lipids in Synaptic Function and Neurological Disease :
Mots-clés :
2-arachidonoylglycerol; 5-HT1A receptor; aging; Alzheimer's; Alzheimer's disease; amyloid pore; amyloid protein precursor; anandamide; annular lipid; bexarotene; bilayer; biochemistry; blood-brain barrier; calcium; ceramide; channel; chaperone; cholesterol; cytolysin; DHA; endocannabinoids; fatty acid; fusion peptide; GalCer; ganglioside; ganglioside lipid rafts; gap junction; glutamate; glycolipid; glycosphingolipid; GM1; GM3; herpes; hexagonal phase; HIV-1; hydrogen bond; intrinsically disordered proteins; ionotropic receptor; JC virus; Langmuir monolayer; Lewy bodies; lipid; lipid polymorphism; lipid raft; listeriolysin O; London forces; membrane; meningitis; metabotropic receptor; micelle; myelin; neurodegenerative disease; NGF receptor; nicotinic acetylcholine receptor GT1b; nonannular lipid; nutrition; oxysterol; packing parameter; Parkinson's; Parkinson's disease; phospholipid; plasma membrane; prion; PrP; purinergic receptor; rotenone; secretase; serotonin; sigma-1 receptor; sphingolipid; sphingosine; sulfatide; synapse; synaptic vesicle; synuclein; synucleopathy; thin layer chromatography; transmembrane domain; tripartite synapse; virus; water