Cancer and IgE, 2010 Introducing the Concept of AllergoOncology

Erika Jensen-Jarolim and Manuel L. Penichet 1. 1 Background Infectious diseases, being the major burden in the history of mankind worldwide th until the beginning of the 20 century, were important triggers in the understanding of immunological mechanisms. In contrast to infectious diseases, reports of all- gies and cancers were less common, but increased tremendously within the last century. Based on the US mortality data of the National Center for Health Statistics, Centers for Disease Control and Prevention 2009, a recent report from the American Cancer Society indicated that the number of cancer deaths increased approximately from 100,000 to 550,000 per year between 1930 and 2006, paralleling the increase of the total population during this period. Leading causes of death from cancer are lung and bronchus cancer, in men prostate cancer, and in women breast c- cer [1, 2]. Normalization to population size shows that the cancer death rate for most malignancies has been generally stable, although the mortality rate of certain malignancies, such as lung and bronchus cancer, has increased over the last 50 years [1-3]. In allergy, the situation is less clear, because for the time period around the turn of th the 19 century, only imprecise information is available. However, within the last 30 years the incidences of allergies has doubled not only in industrial countries, but in developing countries as well [4].

The Biology of IgE: Molecular Mechanism Restraining Potentially Dangerous High Serum IgE Titres In Vivo.- The Biology of IgE: The Generation of High-Affinity IgE Antibodies.- Epidemiological Evidence: IgE, Atopy, and Solid Tumors.- Epidemiological Evidence: IgE, Allergies, and Hematopoietic Malignancies.- Mast Cells in Allergy and Tumor Disease.- The IgE Antibody and Its Use in Cancer Immunotherapy.- IgE Interacts with Potent Effector Cells Against Tumors: ADCC and ADCP.- IgE as Adjuvant in Tumor Vaccination.- The Targets of IgE: Allergen-Associated and Tumor-Associated Molecular Patterns.- The Role of Th2-Mediated Anti-Tumor Immunity in Tumor Surveillance and Clearance.

The first volume based on the field named "AllergoOncology" The term "AllergoOncology", recently created by Dr. Jensen-Jarolim, aims to reveal the function of IgE-mediated immune responses against tumor cells in order to enhance the understanding of its biology and develop novel treatment options based on IgE against malignant diseases Includes supplementary material: sn.pub/extras