Chemotherapy-Induced Neuropathic Pain

There have been tremendous recent advances in the pharmacotherapy, dose regimens, and combinations used to treat cancer and for the treatment or prevention of the spread of disease. As a direct result of these advances, there are an increasing number of cancer survivors, although research dealing with chemotherapy-induced pain is still in its early years.

Written for pain management specialists, oncologists, pharmacologists, students, and primary care practitioners, Chemotherapy-Induced Neuropathic Pain provides insight into the important area of chemotherapy-induced neuropathic pain. It reviews the basic and clinical research into the normal physiology of pain transmission pathways, neuropathic pain pathology, the chemotherapeutic drug mechanisms of action and adverse effects, chemotherapy-induced neuropathy, and drug discovery efforts for treatment.

The contributors comprise an impressive list of clinical and basic science experts in the fields of pain mechanisms and pain management. Included are clinical directors of pain clinics and clinical research facilities, directors of large academic pain research laboratories, analgesic drug developers, and presidents of the International Association for the Study of Pain (IASP), Association of Chronic Pain Patients (ACPP), and the British Pain Society (BPS). Through them, the book provides the reader with an exceptional opportunity to acquire a fundamental understanding of the basic concepts related to this topic.

Chemotherapy-Induced Neuropathic Pain: Clinical Features. Assessment and Grading of Cancer Chemotherapy-Induced Neuropathic Pain. Chemotherapy-Induced Peripheral Neuropathy: Review of Clinical Studies. Orofacial Neuropathy and Pain in Cancer Patients. Cancer Chemotherapy-Induced Neuropathic Pain: The Underlying Peripheral Neuropathy. Bedside to Bench: Research on Chemotherapy-Induced Neuropathic Pain. In Vivo Models and Assessment of Pharmacotherapeutics for Chemotherapy-Induced Neuropathic Pain. Drug Treatment for Chemotherapy-Induced Neuropathic Pain: Amitriptyline as an Example. Experimental Design and Analysis of Drug Combinations Applicable to Chemotherapy-Induced Neuropathic Pain. Central Neuromodulation for Chemotherapy-Induced Neuropathic Pain. Nerve Decompression for Chemotherapy-Induced Neuropathic Pain.

Robert B. Raffa, Ph.D. is Professor and Chair within the Department of Pharmaceutical Sciences at Temple University School of Pharmacy, in Philadelphia, Pennsylvania.

Ronald J. Tallarida, Ph.D. is Professor of Pharmacology at Temple University School of Medicine in Philadelphia, Pennsylvania.

Frank Porreca, Ph.D. is Professor of Pharmacology and Anesthesiology at Temple University in Philadelphia, Pennsylvania.

Joseph V. Pergolizzi, Jr., M.D. is Adjunct Assistant Professor at Johns Hopkins University School of Medicine in Baltimore, Maryland.