Description
Chiral Drugs
Author: Lin Guo–Qiang
Language: EnglishApproximative price 171.58 €
In Print (Delivery period: 12 days).
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Publication date: 07-2011
Description
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Presenting an overview of chiral drugs and their impact on the pharmaceutical industry, Chiral Drugs: Chemistry and Biological Action provides an integrated perspective of chiral drugs from concept, synthesis, and pharmaceutical properties. The book includes important chiral technologies and reviews of 200 chiral drugs that have either been approved or made it to advanced trials. It′s interdisciplinary approach combines synthetic organic chemistry, medicinal chemistry, and pharmacology in a way that fosters cooperation among interdisciplinary scientists and researchers in both academia and the pharma or biotech industries.
ABOUT THE EDITORS vii CONTRIBUTORS ix INTRODUCTION 1 1 OVERVIEW OF CHIRALITY AND CHIRAL DRUGS 3 Guo–Qiang Lin, Jian–Ge Zhang, and Jie–Fei Cheng 2 CHIRAL DRUGS THROUGH ASYMMETRIC SYNTHESIS 29 Guo–Qiang Lin and Xing–Wen Sun 3 CHIRAL DRUGS VIA BIOCATALYTICAL APPROACHES 77 Jianqiang Wang and Wenya Lu 4 RESOLUTION OF CHIRAL DRUGS 137 Qi–Dong You 5 FLUORINE–CONTAINING CHIRAL DRUGS 195 Xiao–Long Qiu, Xuyi Yue, and Feng–Ling Qing 6 INDUSTRIAL APPLICATION OF CHIRAL TECHNOLOGIES 253 Hui–Yin (Harry) Li, Rui Liu, Carl Behrens, and Chao–Ying Ni 7 STRUCTURAL BASIS AND COMPUTATIONAL MODELING OF CHIRAL DRUGS 297 Deping Wang and Eric Hu 8 PHARMACOLOGY OF CHIRAL DRUGS 323 Yongge Liu and Xiao–Hui Gu 9 PHARMACOKINETICS OF CHIRAL DRUGS 347 Hanqing Dong, Xiaochuan Guo and Zengbiao Li 10 TOXICOLOGY OF CHIRAL DRUGS 381 Guang Yang and Hai–Zhi Bu 11 REPRESENTATIVE CHIRAL DRUGS 401 Jiangqin Sun, Dingguo Liu, and Zhimin Wang INDEX 449
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