Cholesterol and Presynaptic Glutamate Transport in the Brain, 2013 SpringerBriefs in Neuroscience Series, Vol. 12

Langue : Anglais

Auteur : Borisova Tatiana

Couverture de l’ouvrage Cholesterol and Presynaptic Glutamate Transport in the Brain

Résumé
Sommaire
Commentaire

Glutamate is the primary excitatory neurotransmitter in the CNS and disturbances in glutamate transport contribute to a number of neurological and neurodegenerative disorders. Appropriate levels of cholesterol are very important for the proper functioning of glutamate transport while unbalanced levels of cholesterol have been implicated in the pathogenesis of disorders such as stroke, ischemia, traumatic brain injury, and neurotoxicity. In the proposed book, the author presents data from the literature and from her own lab to address the extent to and way in which membrane cholesterol modulates presynaptic glutamate transport and whether lowering the level of cholesterol available can offer some neuroprotective benefits.?

Presynaptic glutamate transport in the brain.- Cholesterol and its role in synaptic transmission.- Effects of cholesterol-depleting agent methyl-b-cyclodextrin (MbCD) on the functional state of brain nerve terminals.- The extracellular level and uptake of glutamate in cholesterol-deficient nerve terminals.- Unstimulated and exocytotic glutamate release from cholesterol-deficient nerve terminals.- Neuroprotection by lowering cholesterol.

Reviews the literature on the role of cholesterol in brain function

Examines the neuroprotective aspects of lower cholesterol

Medical doctors will be especially interested in the data on statins?

Includes supplementary material: sn.pub/extras