Clinical Neuroendocrinology Handbook of Clinical Neurology Series

Clinical Neuroendocrinology, a volume in the Handbook of Clinical Neurology Series gives an overview of the current knowledge in the field of clinical neuroendocrinology. It focuses on the pathophysiology, diagnosis, and treatment of diseases of the hypothalamus and the pituitary gland. It integrates a large number of medical disciplines, including clinical endocrinology, pediatrics, neurosurgery, neuroradiology, clinical genetics, and radiotherapy. Psychological consequences of various disorders and therapies, as well as therapeutic controversies, are discussed. It is the first textbook in the field to address all these aspects by a range of international experts.

Section 1 Clinical aspects of hypothalamic function
Development
1. Genetic aspects of hypothalamic and pituitary gland development 
2. Neuroendocrinology of pregnancy and parturition
Vasopressin, oxytocin, CRH
3. Disorders of water metabolism: diabetes insipidus and the syndrome of inappropriate antidiuretic hormone secretion 
4. Oxytocin and vasopressin’s role in emotional and social behaviors 
5. Corticotrophin-releasing hormone and the hypothalamic-pituitary-adrenal axis in psychiatric disease
Metabolism
6. Genetic aspects of human obesity 
7. Sleep characteristics and insulin sensitivity in humans 
8. Hypothalamic neuropeptides in critical illness 
9. Central regulation of the hypothalamo-pituitary-thyroid (HPT) axis – focus on clinical aspects
 
Section 2 Disorders of the pituitary gland
Diagnostic approach
10. Evaluation of pituitary function 
11. Imaging of pituitary pathology
Pituitary pathologies
12. Non-functioning pituitary tumors 
13. Hyperprolactinemia and prolactinoma 
14. Acromegaly 
15. Cushing's disease 
16. Craniopharyngioma 
17. Rathke’s cleft 
18. Alternative causes of hypopituitarism: traumatic brain injury, cranial irradiation and infections
Therapeutic approach to pituitary tumors
19. Surgical approach to pituitary tumors 
20. Medical approach to pituitary tumors 
21. Radiation therapy in the management of pituitary adenomas
 
Section 3 Controversial issues and hot topics
22. Nelson Syndrome, definition and management
23. Familial pituitary tumours 
24. Long-term effects of treatment of pituitary adenomas 
25. Neuroendocrine mechanisms in athletes 
26. Uncertainties in endocrine substitution therapy for central hypocortisolism 
27. Uncertanties in endocrine substitution therapy for central endocrine insufficiencies: Hypothyroidism 
28. Uncertanties in endocrine substitution therapy for central endocrine insufficiencies: growth hormone deficiency 
29. Autoimmune hypophysitis: new developments

Eric Fliers is Professor of Endocrinology at the University of Amsterdam, serving as head of the Department of Endocrinology and Metabolism at the Academic Medical Center in Amsterdam since 2007. He received a PhD in Neuroscience on the functional neuroanatomy of the human hypothalamus, followed by his MD (with honors), both from the University of Amsterdam. He was subsequently trained as an internist-endocrinologist. Fliers was one of the founders of the Netherlands Brain Bank. His current research interests include the hypothalamus-pituitary-thyroid axis, and the neuro-endocrine response to illness. Eric Fliers is the current chair of the Dutch Endocrine Society.
Prof. Márta Korbonits is a clinical academic endocrinologist with special interest in pituitary tumorigenesis and as well as metabolic effects of hormones. She graduated in medicine at Semmelweis Medical School in Budapest and works in the Department of Endocrinology at Barts and the London School of Medicine at St. Bartholomew’s Hospital in London since 1991, where currently she is Co-Centre Head. She received an MD and a PhD from the University of London and was a recipient of a Medical Research Council Clinician Scientist Fellowship to study ghrelin physiology and genetics. Her current interests include hormonal regulation of the metabolic enzyme AMP-activated protein kinase, the physiology and pathophysiology of ghrelin and endocannabinoids and pituitary tumours including familial cases. She has a large collection of familial isolated pituitary adenoma families and works on both the clinical characterization as well as molecular aspects of this disease.

She has published over 160 papers, numerous book chapters, and edited two books in the field of Endocrinology and has been an invited speaker on medical conferences all over the world. She serves on the editorial board of several prestigious endocrine journals and serves as referee for numerous high-impact journals and grant-giving bodies. She w