Colloid and Interface Science in Pharmaceutical Research and Development

Coordinators: Ohshima Hiroyuki, Makino Kimiko

Language: English
Cover of the book Colloid and Interface Science in Pharmaceutical Research and Development

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532 p. · 19x23.3 cm · Hardback

Colloid and Interface Science in Pharmaceutical Research and Development describes the role of colloid and surface chemistry in the pharmaceutical sciences. It gives a detailed account of colloid theory, and explains physicochemical properties of the colloidal-pharmaceutical systems, and the methods for their measurement.

The book starts with fundamentals in Part I, covering fundamental aspects of colloid and interface sciences as applied to pharmaceutical sciences and thus should be suitable for teaching. Parts II and III treat applications and measurements, and they explains the application of these properties and their influence and use for the development of new drugs.

Part I Fundamentals

Interaction between drugs

Pharmaceutical suspensions

Response of colloidal drugs to external fields

Aggregation of drugs

Concentrated drug particles

Rheology of colloidal suspensions

Part II Applications of Colloid and Interface Science in Pharmaceutical sciences

Liposomes and micelles

Binding of drugs on liposomes

Drug delivery system

Gold nanoparticles

Drug permeation through biological membranes

EPR effects

Part III Measurements

Zeta potential of colloidal drugs

Atomic force microscope

Surface force apparatus

Primary Market: Scientists, engineers, and students in the field of pharmaceutical science who want to understand colloid and interface science. This book can be used both for teaching and research.

Secondary Market: Scientists, engineers, and students in the field of colloid and interface science who want to understand pharmaceutical science.

Hiroyuki Ohshima is Professor Emeritus at the Tokyo University of Science, Japan. He received the B.S. (1968), M.S. (1970), and Ph.D. (1974) degrees in physics from the University of Tokyo. He spent his post-doc study at University of Melbourne, Australia (1981-1983), State University of New York at Buffalo, USA (1983-1984), and University of Utah, USA (1984-1985). He has worked at the Tokyo University of Science, Japan since 1985. He was previously a Professor of Pharmaceutical Sciences at the Tokyo University of Science (1994-2012) and is now a Professor Emeritus and a Visiting Professor.

He is the author of Theory of Colloid and Interfacial Electric Phenomena (Elsevier, 2006) and Biophysical Chemistry of Biointerfaces (Wiley, 2010). He edited Electrical Phenomena at Interfaces and Biointerfaces (Wiley, 2012) and Encyclopedia of Biocolloid and Biointerface Science (Wiley, 2016). He co-edited Electrical Phenomena at Interfaces. 2e (Marcel Dekker, 1998) and Colloid and Interface Science in Pharmaceutical Research and Development (Elsevier, 2014).



He is also the author or co-author of over 400 book chapters and journal publications, reflecting his research interests in colloid and interface science. He was an Editor of the journal Colloids and Surfaces B: Biointerfaces (1994-2012, Elsevier) and currently he is an Associate Editor of Colloid and Polymer Science (2002-present, Springer).

In 2016, Ohshima was awarded the 29th Khwarizmi International Award by the Iranian Research Organization for Science and Technology for his contribution to the theory of colloid and interfacial electric phenomena. In 2017, he was selected as one of Asia's top 100 scientists for 2017 (The Asian Scientist Magazine, June 2017). In 2022, he was awarded Fellow of Japan Oil Chemists' Society. On January 13, 2021, the layman's summary of Ohshima’s research article:?Gel Electrophoresis of a Soft Particle (Adv. Colloid Interface Sci., 271, 101977, 2019)?was publ
  • Provides a clear description of the fundamentals of colloid and interface science relevant to drug research and development
  • Explains the physicochemical/colloidal basis of pharmaceutical science
  • Lists modern experimental characterization techniques, provides analytical equations and explanations on analyzing the experimental data
  • Describes the most advanced techniques, AFM (Atomic Force Microscopy), SFA (Surface Force Apparatus) in detail