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DNA Topoisomerases and Cancer, 2012 Cancer Drug Discovery and Development Series

Langue : Anglais

Coordonnateur : Pommier Yves

Couverture de l’ouvrage DNA Topoisomerases and Cancer

DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.

Introduction and Historical Perspective.- Human DNA topoisomerase I: Structure, Enzymology and Biology.- Mitochondrial topoisomerases.- Structure and mechanism of eukaryotic type IIA topoisomerases.- Essential functions of topoisomerase III in the nucleus and mitochondria.- DNA topoisomerase I and illegitimate recombination.- Topoisomerase-induced DNA damage.- Topoisomerases and carcinogenesis: Topo III and BLM.- Topoisomerase inhibitors: a paradigm for interfacial inhibitors.- Topoisomerase I inhibitors: chemical biology.- Topoisomerase II inhibitors: chemical biology.- Topoisomerase I inhibitors: current use and prospects.- Topoisomerase II inhibitors: current use and prospects.- Transcription stress by camptothecin: mechanism and implication for the drug antitumor activity.- Mechanism regulating cellular responses to DNA topoisomerase I-targeted agents.- Tyrosyl-DNA-phosphodiesterase.- Ubiquitin and ubiquitin-like proteins in repair of topoisomerase-mediated DNA damage.- Repair of topoisomerase II-mediated DNA damage: fixing DNA damage arising from a protein covalently trapped on DNA.- Topoisomerases and Apoptosis.- Index.
Structure and mechanism of eukaryotic type IIA topoisomerases DNA topoisomerase I and illegitimate recombination Mechanism regulating cellular responses to DNA topoisomerase I-targeted agents

Ouvrage de 443 p.

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Prix indicatif 216,90 €

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Ouvrage de 443 p.

15.5x23.5 cm

Sous réserve de disponibilité chez l'éditeur.

Prix indicatif 232,09 €

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