Enzootic Bovine Leukosis and Bovine Leukemia Virus, Softcover reprint of the original 1st ed. 1987
Developments in Veterinary Virology Series, Vol. 2

This volume on enzootic bovine leukosis (EBL) and bovine leukemia virus (BLV) is the second in our series "Developments in Veterinary Virology". Each book in this series is devoted to a major virus disease of agricultural significance. The chapters in each volume are planned to supply information on a range of subjects from pathogenesis of the causative virus to vaccination, eradication, and rules regarding disease control. The present volume on enzootic bovine leukosis and bovine leukemia virus updates the reader on the disease and its causative agent and includes the nucleotide sequence of the BLV genome as well as data on its integration into the DNA of the tumor cell. Insights into diagnosis, veterinary legislation, and the economic aspects of EBL are also provided. Intense research conducted on EBL and BLV during the course of a decade is presented in a most concise and in-depth manner, so as to provide the reader with a comprehensive overview of this economically important disease of cattle. I wish to thank the editors, A. Burny and M. Mammerickx, as well as all the authors, for making this excellent book available at a stage when the knowledge on bovine leukemia virus will also contribute to our understanding of the virus causing human AIDS.

History.- 1. History and terminology of enzootic bovine leukosis.- Course of the disease and clinical features.- 2. Pathology of enzootic bovine leukosis. Comparison with the sporadic form.- 3. The epidemiology of enzootic bovine leukosis.- Economics.- 4. Economics of enzootic bovine leukosis.- Bovine leukemia virus.- 5. Discovery of bovine leukemia virus.- 6. Morphology of bovine leukemia virus.- 7. In vitro propagation of bovine leukemia virus.- 8. Genetic structure of bovine leukemia virus genome and biosynthesis of bovine leukemia virus proteins.- 9. Sequence analysis of the bovine leukemia virus genome.- 10. Transforming activity of bovine leukemia virus and properties of tumor-associated antigen on bovine lymphosarcoma.- 11. Leukemogenesis by bovine leukemia virus.- Immunology.- 12. Immunological aspects of enzootic bovine leukosis.- Detection of bovine leukemia virus infection.- 13. Detection of bovine leukemia virus infection by nonspecific methods; hematology and tumor screening.- 14. Detection of bovine leukemia virus infection by immunodiffusion and radioimmunoassay.- 15. The immunodiffusion tests for the detection of bovine leukemia virus-infected animals.- 16. ELISA, a highly sensitive and specific method for diagnosis of bovine leukemia virus infection.- 17. VSV(BLV) pseudotypes.- Transmission.- 18. Natural and experimental transmissions of bovine leukemia virus.- Control.- 19. Control of enzootic bovine leukosis in Denmark.- 20. Eradication of enzootic bovine leukosis in Lower Saxony.- 21. Control and eradication of the disease in the EEC.