Gene Expression and Regulation

This book offers a comprehensive look into the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. Presented in five sections, this book covers the full spectrum: The History, The Machinery, The Regulators, The Genome, and Special Topics. The Machinery section covers the transcriptional apparatus and general transcription factors. The Regulators section examines selected gene-specific transcription factors important to regulating gene expression. The Genome section covers issues relevant to the behavior of the genome in relation to gene regulation. The Special Topics section discusses several selected topics ranging from bacterial and plant gene expression to DNA topology. The book's focus is on scientific concepts and issues, rather than specific organisms or experimental approaches.

Section I: The History * 1. Transcription--Then and Now, * Section II: The Machinery * 2. GTFs, PIC Information, * 3. RNA Polymerase Holoenzyme, * 4. Mediators/Adaptors, TBP and TAFs, * 5. Chromation and Chromation Remodeling, * 6. HATs and HDACs, * 7. Core Promoter Elements, * Section III: The Regulators * 8. Activators and Activation Mechanisms, * 9. Repressors and Repression Mechanisms, * 10. STATs, * 11. Smads, * 12. RB-E2F, * 13. AP-1, * 14. HIV Tat, * 15. p53, * 16. Actions of Nuclear Receptors, * 17. NFAT, * 18. Homeodomain Proteins, * 19. NFkB/Rel, * 20. ATFs, * Section IV: The Genome * 21. Insulators and Chromatin Boundaries, * 22. Heterochromatin and X Inactivation, * 23. DNA Methylation and Imprinting, * 24. Genomics and Transcription, * 25. DNA Synthesis/Integrity and Transcription, * 26. Cell Death and Transcription, * Section V: Special Topics * 27. RNA Processing, * 28. DNA Topology and Transcription, * 29. miRNA and RNAi, * 30. Developmental Signals and Transcription, * 31. Gene Expression in Plants, * 32. Bacterial Gene Regulation, * 33. Gene Therapy, * 34. Transcription Factor Dynamics, * 35. Actin, Myosin, and ARPs in Transcription