Description
Genome Editing in Neurosciences, Softcover reprint of the original 1st ed. 2017
Research and Perspectives in Neurosciences Series
Coordinators: Jaenisch Rudolf, Zhang Feng, Gage Fred
Language: EnglishSubjects for Genome Editing in Neurosciences:
Publication date: 08-2018
Support: Print on demand
Publication date: 09-2017
Support: Print on demand
Description
/li>Contents
/li>Biography
/li>Comment
/li>
This book is open access under a CC BY 4.0 license.
CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease.
This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
Introduction.- In vitro modeling of complex neurological diseases.- Aquatic model organisms in neurosciences : the genome editing revolution.- Genome-wide genetic screening in the mammalian CNS.- CRISPR/Cas9-mediated Knockin and Knockout in Zebrafish.- Dissecting the role of synaptic proteins with CRISPR.- Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer.- Neuroscience research using non-human primate models and genome editing.- Multiscale genome engineering: Genome-wide screens and targeted approaches.- Using Genome Engineering to Understand Huntington’s Disease.- Therapeutic gene editing in muscles and muscle stem cells.
Highlights how genome editing is enabling breakthroughs in how we study the brain
Identifies a powerful method to understand and treat central nervous system disorders
Reveals system-level insight into how the nervous system develops and functions
Includes supplementary material: sn.pub/extras