Genomic and Precision Medicine (3rd Ed.)
Foundations, Translation, and Implementation

Coordinators: Ginsburg Geoffrey S., Willard Huntington F

Language: English
Cover of the book Genomic and Precision Medicine

Subject for Genomic and Precision Medicine

Keywords

16S ribosomal RNA; Adaptive designs; Adverse effects; Analytical standards; Bias; Biobanking; Bioinformatics; Biomarkers; Biomedical informatics; CMS; Chemical individuality; Chromatin; Citizen scientist; Clinical data; Clinical data sharing; Clinical decision support; Clinical test; Clinical utility; Collaboration; Computer science; Cost; Cost-benefit analysis; DNA; DNA methylation; Data science; Data sharing; Decision model; Deliberative engagement; Disease modified; Drug response; EGCUT; ELSI; Effectiveness; Effectiveness-implementation hybrid trial; Efficacy; Electronic health records; Environmental exposures; Epigenetics; Epigenome; Estonian Biobank; Ethics; Evaluation; Evidence-based medicine; Exome; FDA; FDA regulation; FFPE; Family health history; Genetic clinical decision support; Genetic database; Genetic test; Genetics; Genome; Genome sequencing; Genome variation; Genomic; Genomic data; Genomic exceptionalism; Genomic medicine; Genomic technology; Genomic testing; Genomics; Global Alliance for Genomics and Health; HGRA; Health outcomes; Health technology assessment; Histone modifications; Human genome; Implementation; Implementation science; In vitro diagnostic; Individualized medicine; Infobuttons; Informatics; Knowledge alerts; Knowledge framework; Knowledge management; Laboratory-developed test; Law; Learning healthcare system; Mass spectrometry; Mayo; Meaningful use; Media messages; Medical device; Metagenomics; Microbial communities; Microbiome; Molecular genetic test; Multiple comparisons; Myriad; Next-generation sequencing; Outcome; PCR; Patentable subject matter; Patient-centered; Patient-entered data; Patient-provider communication; Personalized medicine; Pharmacogenomics

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Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care.

The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care.

1. Application of Human Genome Information to Clinical Practice
2. Translating genome information into clinical practice and human health
3. Big Data and Translational Bioinformatics Genomic and Personalized Medicine
4. Designing Genome-Based Clinical Studies
5. Developing the Evidence to Support Clinical Use Genomic Biomarkers as Diagnostics
6. Health Risk Assessment and Family History
7. Clinical Decision Support
8. Implementation Science and Integration into Healthcare Systems
9. Pharmacogenetics and Pharmacogenomics
10. Drug Repurposing and Repositioning
11. Point of Care Devices
12. Overview of Policy, Ethical and Social Considerations
13. Educational Issues and Strategies for Genomic Medicine
14. Regulation of Genomic Technologies
15. Economic Value of Genomic Medicine
16. Reimbursement
17. Impact of Patents on Genomic Medicine
Medical students, life sciences and engineering graduate students, advanced undergraduate students, residents and fellows working with any aspect of genomic research in the life sciences and/or medicine, educators, and translational scientists. This volume will also be of interest to translational researchers, implementation scientists, outcomes researchers, policy analysts and policy makers
Dr. Ginsburg is the founding Director of the Center for Applied Genomics & Precision Medicine in the Duke Institute for Genome Sciences & Policy. He is also Professor of Medicine and of Pathology at Duke University Medical Center, Professor of Biomedical Engineering at Duke Pratt School of Engineering, and Co-Director of the Duke Translational Medicine Institute.
Huntington Willard is on the faculty of the Department of Human Genetics at the University of Chicago. Prior to this appointment, Willard was the President and Director of the Marine Biological Laboratory and Professor of Human Genetics at the University of Chicago. He was previously on the faculty at Duke University, where he was founding director of the university-wide Duke Institute for Genome Sciences & Policy from 2003 to 2014, the Nanaline H. Duke Professor of Genome Sciences, and the Arts & Sciences Professor of Biology & Genome Sciences.
  • Provides a comprehensive volume on the translation and implementation of biology into health care provision
  • Presents succinct commentary and key learning points that will assist readers with their local needs for translation and implementation
  • Includes an up-to-date overview on major ‘translational events’ in genomic and personalized medicine, along with lessons learned