Handbook for Chemical Process Research and Development
Auteur : Zhao Wenyi
The Handbook for Chemical Process Research and Development focuses on developing processes for chemical and pharmaceutical industries. Forty years ago there were few process research and development activities in the pharmaceutical industry, partially due to the simplicity of the drug molecules. However, with the increasing structural complexity, especially the introduction of chiral centers into the drug molecules and strict regulations set by the EMA and FDA, process R&D has become one of the critical departments for pharmaceutical companies. This book assists with the key responsibility of process chemists to develop chemical processes for manufacturing pharmaceutical intermediates and final drug substances for clinical studies and commercial production.
- Chapter 1: Modes Of Reagent Addition – Control of Impurity Formation
- Chapter 2: Process Optimization
- Chapter 3: Hazardous Reactions
- Chapter 4: Catalytic Reactions
- Chapter 5: Grignard Reagent And Related Reactions
- Chapter 6: Challenging Reaction Intermediates
- Chapter 7: Protecting Groups
- Chapter 8: Reaction Solvents
- Chapter 9: Base Reagent Selection
- Chapter 10: Reagents For Amide Formation
- Chapter 11: Various Reagent Surrogates
- Chapter 12: Telescope Approach
- Chapter 13: Stereochemistry
- Chapter 14: Design Of New Synthetic Route
- Chapter 15: Reaction Workup
- Chapter 16: Pharmaceutical Salts
- Chapter 17: Solid Form
Dr. Wenyi Zhao, Senior Research Scientist (Process Chemistry), Member of the American Chemical Society. 1980–1990: Ph.D., Organic/Physical Organic Chemistry, Nanjing University, China. 1990–1992: Postdoctoral fellow at the Institute of Chemistry, Chinese Academy of Sciences, Beijing. 1992–1995: Associate Professor at the Institute of Photographic Chemistry, Chinese Academy of Sciences, Beijing (now the Institute of Chemistry, Chinese Academy of Sciences, Beijing). 1995–2001: Senior Research Associate in the Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas. Early in 2001, Dr. Zhao moved into the private sector to become a process chemist in the pharmaceutical industry in the United States. He is the author of numerous journal articles and holds several patents.
Date de parution : 06-2020
17.8x25.4 cm
Disponible chez l'éditeur (délai d'approvisionnement : 14 jours).
Prix indicatif 56,31 €
Ajouter au panierDate de parution : 09-2016
17.8x25.4 cm
Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).
Prix indicatif 220,72 €
Ajouter au panierThèmes de Handbook for Chemical Process Research and Development :
Mots-clés :
Grignard Reagent; SNAr Reaction; Synthetic organic chemistry; Chemical Process Research; Process chemistry; Salt Formation; Scaling up; Grignard Reaction; Mechanism-guided process development; Ammonium Formate; Chemical processes; Procedure Stage; Process research and development; Potassium Tert Butoxide; Stereochemistry and asymmetric; Carboxylic Acid; Nucleophilic Aliphatic Substitution; Amide Formation; Active Pharmaceutical Ingredients; Chiral Auxiliary; Phosphorus Oxychloride; Nitro Group; Weinreb Amide; NaOH Solution; Diastereomeric Salts; Triethylamine Hydrochloride; Methyl Tert Butyl Ether; Unstable; MeOH; Catalytic Amount; Route Ii; Nitro Product