Human Cell Transformation, Softcover reprint of the original 1st ed. 2012
Role of Stem Cells and the Microenvironment
Advances in Experimental Medicine and Biology Series, Vol. 720

Rhim and Kremer?s state-of-the-art volume on Human Cell Transformation: Role of Stem Cells and the Microenvironment highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells.

Chapters cover all recently developed novel human cell models. In addition, the rapidly growing fields of knowledge regarding not only stem cells in cancer progression, but also the role of the microenvironments in human carcinogenesis are discussed. A wealth of topics is presented including:

·         Derivation of epithelial, fibroblastic, and hematopoietic in vitro model systems

·         Oncogenes

·         Tumor suppressor genes

·         Viral transformation

·         In vitro model systems for viral, chemical and radiation carcinogenesis

·         Cell aging

·         The multistep nature of human carcinogenesis

·         The genes involved in multistep carcinogenesis

Unique in both scope and focus ? devoted solely to human cell transformation systems ? Human Cell Transformation: Role of Stem Cells and the Microenvironment provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields.

Essential reading for everyone who needs to be kept up-to-date in this fast-paced area!

Features

Ø  Multistep models

Ø  Breast cancer/Stem cells

Ø  Prostate cancer/Stem cells

Ø  Multistep / Genes

Nuclear Barrier Hypothesis of Aging as Mechanism for Tradeoff Growth to Survival.- Establishment of Cell Lines from the Human Middle and Inner Ear Epithelial Cells.- Cellular Systems for Studying Human Oral Squamous Cell Carcinomas.- Heterotopic Ossification Following Musculoskeletal Trauma: Modeling Stem and Progenitor Cells in Their Microenvironment.- Comparative Proteomic Analysis of Mesenchymal Stem Cells Derived from Human Bone Marrow, Umbilical Cord, and Placenta: Implication in the Migration.- Novel Human Prostate Epithelial Cell Culture Models for the Study of Carcinogenesis and of Normal Stem Cells and Cancer Stem Cells.- Prostate Tumor Cell Plasticity: A Consequence of the Microenvironment.- Role of Epigenetics in Cancer Initiation and Progression.- Cancer Stem Cells, Models of Study and Implications of Therapy Resistance Mechanisms.- The Role of the Basal Stem Cell of the Human Breast in Normal Development and Cancer.- Breast Cancer Subtypes: Two Decades of Journey from Cell Culture to Patients.- Parathyroid Hormone Related Protein (PTHrP) in Tumor Progression.- Mechanism of Radiation Carcinogenesis: Role of the TGFBI Gene and The Inflammatory Signalling Cascade.- Histone Deacetylase Inhibitors: Anti-Neoplastic Agent and Radiation Modulator.- Human Fibroblasts for Large-Scale “Omics” Investigations of ATM Gene Function.- Malignant Transformation of Human Skin Fibroblasts by Two Alternative Pathways.- A Novel Tumor Suppressor, REIC/Dkk-3 Gene Identified By Our In Vitro Transformation Model of Normal Human Fibroblasts Works as a Potent Therapeutic Anti-Tumor Agent.