Hyperlipidaemia
Oxford Cardiology Library Series

In the last decade, advances in the understanding of lipoprotein and lipid metabolism have developed enormously. This has resulted in a detailed knowledge of the mechanisms underlying the primary and secondary dyslipidaemias. Furthermore, the role of lipoproteins in atherogenesis is increasingly understood at the cellular and molecular level. In this book, the scale of the problem of cardiovascular disease (CVD) is described together with the possibilities for prevention. The pathophysiology of lipid and lipoproteins provide a background to the understanding of the primary and secondary dyslipidaemias and the mechanism of action of the different drug classes. A practical approach to therapy is provided including diet, lifestyle, and therapeutic approaches. Common clinical problems are addressed and the book looks to the future, principally in relation to new therapeutic targets. This book provides the basis for the translation of clinical trial science into everyday clinical practice for the benefit of the individual patient.

1. Epidemiology of cardiovascular disease: the scale of the problem. 2. Lipids, lipoproteins and atherogenesis. 3. Risk estimation systems in clinical use: SCORE, HeartScore, Framingham, PROCAM, ASSIGN and QRISK. 4. Primary dyslipidaemias. 5. Secondary dyslipidemias. 6. Diet and lifestyle. 7. Pharmacological therapy: Statins. 8. Pharmacological therapy: Non-Statin Drugs. 9. Combination therapy for the management of hyperlipidaemia. 10. Recent lipid-lowering trials in perspective: Implications for therapy. 11. Vascular imaging. 12. Common problems in lipid management.