Ion Channels


Language: Anglais

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Ion channels provide a unique opportunity to use computationalapproaches to attempt an understanding of the function of amembrane protein, starting with an atomic resolution structure andprogressing through a hierarchy of theoretical descriptions untilone can account quantitatively for their physiological function.This book brings together physiologists, structural biologists andtheorists who came together to help define the direction of thefield in the immediate future.
Topics covered include:
∗ the x–ray structure of channels and pores
∗ computer simulation of channel function
∗ detailed data on potassium channels, chloride and calciumchannels, and ligand–gated ion channels
Introduction: stretching the envelope in structure–function studiesof ion channels (M. Sansom)

Structure of acetylcholine–gated channel (N. Unwin)

The 2.7 A structure of AChBP, homologue of the ligand–buildingdomain of the nicotonic acetylcholine receptor (K. Brejc, etal.)

The architecture of a water–selective pore in the lipid bilayervisualized by electron crystallography in vitreous ice (A. Mitra,et al.)

The structure of Glpf, a glycerol conducting channel (D. Fu,et al.)

Water in ion channels and pores simulation studies (M.Sansom, et al.)

What can be deduced about the structure of Shaker from availabledata? (B. Roux)

Permeation energetics in a model potassium channel (S. Garofoli,et al.)

The subunit of Kv1 channels: voltage–gatedenzyme or safety switch? (J. Gulbis)

EPR approaches to ion channel structure and function (E. Perozo,et al.)

Excitability is mediated by the T1 domain of the voltage–gatedpotassium channel (S. Choe, et al.)

Structural organization of the voltage sensor involtage–dependent potassium channels (D. Papazian, etal.)

Electron diffraction of a bacterial CIC –type chloride channel(M. Pirruccello, et al.)

A protein chemical approach to channel structure and function:the proton channel of the vacuolar H+–ATPase (J.Findlay and M. Harrison)

Acetylcholine receptors, between closed and open (A.Auerbach)

Functional genomics of ionotropic acetylcholine receptors inCaenorhabditis elegans and Drosophilia melanogaster (D. Satelleet al.)

Final General Discussion

Index of Contributors

Subject Index