Mechanisms of Lymphocyte Activation and Immune Regulation III, Softcover reprint of the original 1st ed. 1991
Developmental Biology of Lymphocytes
Advances in Experimental Medicine and Biology Series, Vol. 292

Recent advances in the understanding of the major events that shape the immune recog­ nition system have been remarkable. The analysis of immunoglobulin (Ig) gene organization and Ig repertoire diversification in lower vertebrates has provided new insight into this process in mammals. Similarly, the understanding of the early development of lymphocytes and of the acquisition of immunological tolerance has been aided by elegant studies in quail/chicken chimeras, using the power of the distinctive markers of the constitutive cells of these birds. Great strides have been made in understanding the role played by major histocompatibility complex (MHC) molecules in antigen presentation and in repertoire selec­ tion within the thymus. The use of transgenic mice expressing specific T-cell receptor (TCR) genes has elucidated the process of both positive and negative selection. In parallel, there has been considerable progress in our understanding of tolerance, based in part on the use of markers for the V fJ genes of T-cell receptors and in part on the analysis of the behavior of long term T-cell lines. This has led to the realization that both clonal deletion and clonal anergy may play critical roles in the maintenance of unresponsiveness to self antigen. Molecular analysis of the requirements for expression of membrane immunoglobulin molecules has revealed the existence of a complex that appears to be of critical importance in mediating signalling through Ig receptors. In addition, major insights have been obtained into the regulation of expression of genes of immunologic interest.

Phylogeny of Lymphocytes.- Immunoglobulin Genes and B Cell Development in Amphibians.- Evolutionary Development of Immunoglobulin Gene Diversity.- Studies on the Ontogeny of the Immune Function in Birds.- Developmental Biology of T Lymphocytes.- Kinetics of Negative and Positive Selection in the Thymus.- Life and Death of a T Cell.- First Wave Fetal Thymocytes Expressing V3j?1?1C?l-V?1J?2C? T Cell Receptors Are Not Required for ?? T Cell Receptor Rearrangement and Expression.- Diversity, Development, Ligands, and Probable Functions of ?? T Cells.- ?? T Cells in Murine Epithelia: Origin, Repertoire, and Function.- Acquisition of Mature Functional Responsiveness in T Cells: Programming for Function via Signaling.- Molecular Analysis of the Interaction of p56lck with the CD4 and CD8 Antigens.- Characterization of Triple Negative Clones Isolated from Post-Natal Human Thymus.- Monoclonal Antibodies Against T Cell Receptor/CD3 Complex Induce Cell Death of Thl Clones in the Absence of Accessory Cells.- Identification of a Novel Thymocyte Growth Factor Derived from B Cell Lymphomas.- Expression of Receptors for Interleukin 4 and Interleukin 7 on Human T Cells.- Effects of Leukemia Inhibitory Factor (LIF) on Gene Transfer Efficiency into Murine Hematolymphoid Progenitors.- Mechanism of Tolerance Inductions.- Thymic Mechanisms for Inducing Tolerance to Mls.- Cells Inducing Tolerance to Mls and H-2 Antigens.- Multiple Mechanisms of T cell Tolerance to Mls-la.- Induction and Maintenance of Anergy in Mature T Cells.- Developmental Biology Of B Lymphocytes.- Cloning and Characterization of a Protein Binding to the Jk Recombination Signal Sequence of Immunoglobulin Genes.- In Situ Detection of Stage-Specific Genes and Enhancers in B Cell Differentiation via Gene-SearchRetroviruses.- B Cell Development in Fetal Liver.- Identification of Components of the B Cell Antigen Receptor Complex.- Differences in Human B Cell Differentiation.- Stromal Cell Lines which Support Lymphocyte Growth. II. Characteristics of a Suppressive Subclone.- Developmental Biology Of Immunoglobulins.- Restricted Utilization of Germ-Line VH Genes in Rabbits: Implications for Inheritance of VH Allotypes and Generation of Antibody Diversity.- Control of Immunoglobulin Heavy Chain Constant Region Gene Expression.