Molecular Basis of Oxidative Stress
Chemistry, Mechanisms, and Disease Pathogenesis

Focusing on the molecular and chemical bases of oxidative stress, which can cause cancer as well as cardiovascular and neurodegenerative diseases, Molecular Basis of Oxidate Stress discusses the role of free radicals in disease, diagnosis, and therapeutics. Written by recognized leaders in the field, the book provides in–depth knowledge about the mechanisms of oxidative stress and damage, free radical chemistry, and the role of free radicals in disease, diagnosis, and therapeutics.

Preface xvii About the Contributors xix Contributors xxv 1 Chemistry of Reactive Species 1 Frederick A. Villamena 2 Lipid Peroxidation and Nitration 49 Sean S. Davies and Lilu Guo 3 Protein Posttranslational Modifi cation 71 James L. Hougland, Joseph Darling, and Susan Flynn 4 DNA Oxidation 93 Dessalegn B. Nemera, Amy R. Jones, and Edward J. Merino 5 Downregulation of Antioxidants and Phase 2 Proteins 113 Hong Zhu, Jianmin Wang, Arben Santo, and Yunbo Li 6 Mitochondrial Dysfunction 123 Yeong–Renn Chen 7 NADPH Oxidases: Structure and Function 137 Mark T. Quinn 8 Cell Signaling and Transcription 179 Imran Rehmani, Fange Liu, and Aimin Liu 9 Oxidative Stress and Redox Signaling in Carcinogenesis 203 Rodrigo Franco, Aracely Garcia–Garcia, Thomas B. Kryston, Alexandros G. Georgakilas, Mihalis I. Panayiotidis, and Aglaia Pappa 10 Neurodegeneration from Drugs and Aging–Derived Free Radicals 237 Annmarie Ramkissoon, Aaron M. Shapiro, Margaret M. Loniewska, and Peter G. Wells 11 Cardiac Ischemia and Reperfusion 311 Murugesan Velayutham and Jay L. Zweier 12 Atherosclerosis: Oxidation Hypothesis 329 Chandrakala Aluganti Narasimhulu, Dmitry Litvinov, Xueting Jiang, Zhaohui Yang, and Sampath Parthasarathy 13 Cystic Fibrosis 345 Neal S. Gould and Brian J. Day 14 Biomarkers of Oxidative Stress in Neurodegenerative Diseases 359 Rukhsana Sultana, Giovanna Cenini, and D. Allan Butterfield 15 Synthetic Antioxidants 377 Grégory Durand References, 398 Index 407

FREDERICK A. VILLAMENA, PhD, is Associate Professor in the Pharmacology Department of The Ohio State University. Dr. Villamena performs extensive research to develop radical probes and synthetic antioxidants for the treatment of radical-mediated injury such as myocardial infarction. His research draws from many fields, including computational chemistry, organic synthesis, spectroscopy, and molecular biology.