Non-Invasive Sperm Selection for In Vitro Fertilization, 2015
Novel Concepts and Methods

Non-Invasive Sperm Selection for In Vitro Fertilization summarizes and discusses the relevant literature on the various advanced sperm selection methods used in modern Assisted Reproductive Technologies (ART). Chapters review some of the major unresolved issues in the field, the feasibility and success of the various sperm selection methods, their safety and the effects they have on sperm quality and ART outcomes. The book makes recommendations on clinical applications and future research, while helping to elucidate the benefits and promise of non-invasive sperm selection techniques. A distinguished team of scientists, embryologists, and urologists, with expertise in male infertility and ART, contributes to this original and valuable reference guide meant for academics, researchers, and professionals in the field of reproductive medicine who need an update on the current status of the study and practice of non-invasive sperm selection techniques.

Male Infertility Laboratory Investigation: A Critical Analysis of the 2010 World Health Organization Semen Analysis Guidelines.- Intracytoplasmic Injection with Suboptimal Spermatozoa.- Novel Sperm Tests and Their Importance.- Sperm Selection Based on Surface Electrical Charge.- Microfluidics for Sperm Selection.- Sperm Binding to Zona Pellucida, Hyaluronic Acid Binding Assay and PICSI.- Non-Apoptopic Sperm Selection.- Motile Sperm Organelle Morphology Examination (MSOME).- Setup of Micromanipulator for Sperm Selection and Injection for IMSI.- Configuring the Microscope for Intracytoplasmic Morphology-Selected Sperm Injection (IMSI).- The Technical Background of Advanced IMSI Systems.- Sperm Vacuoles: Origin and Implications.- MSOME: Conventional Semen Analysis, Sperm Manipulation, and Cryopreservation.- MSOME and Sperm Chromatin Status.- MSOME and Sperm DNA Integrity: Biological and Clinical Considerations.- MSOME and Sperm Chromosomal Constitution.- Intracytoplasmic Morphologically Selected Sperm Injection (IMSI): Indications and Clinical Results.- Genomic and Proteomic Approaches in the Diagnosis of Male Infertility.

Ashok Agarwal, PhD, HCLD (ABB), ELD (ACE), Lerner College of Medicine, Andrology Center, Case Western Reserve University, Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA

Edson Borges Jr., MD, PhD, Fertility - Centro de Fertilização Assistida, Associação Instituto Sapientiae - Centro de Estudos e Pesquisa em Reprodução Assistida, São Paulo, Brazil

Amanda S. Setti, BSc, Fertility - Centro de Fertilização Assistida, Associação Instituto Sapientiae - Centro de Estudos e Pesquisa em Reprodução Assistida, São Paulo, Brazil

Reviews and assesses recent developments in sperm selection for ART, including the use of Motile Sperm Organelle Morphology Examination (MSOME)

The first text available on MSOME and microinjection of morphologically selected sperm (IMSI) that enlightens readers on new developments in the field of sperm selection techniques

Edited and written by a group of skilled scientists and urologists who are specialists in male infertility