Organism Models of Autism Spectrum Disorders, Softcover reprint of the original 1st ed. 2015
Neuromethods Series, Vol. 100

As autism is associated with many rare diseases, this extensive bench book examines how no one single model can be used; multiple organism models are needed, each one corresponding to one of the diseases or to one aspect of a disease. Split into five sections, Organism Models of Autism Spectrum Disorders explores selecting the good species for the specific disease, modeling autism spectrum disorders (ASD) at the brain level, studying communication and social interactions, using vertebrates or invertebrate models of ASD as defined by DSM-5R, as well as pursuing models of diseases associated with an increased incidence of ASDs. Written for the respected Neuromethods series, this detailed volume contains the kind of insight and useful, practical advice that ensures more successful results in the lab.

Comprehensive and handy, Organism Models of Autism Spectrum Disorders will benefit psychiatrists and geneticists, as well as behavioral researchers who, realizing how important it is to improve their knowledge through more molecular approaches, are looking for the most suitable organisms.

Part I: Organism Models of Autism Spectrum Disorders: Selecting the Good Species

1. Organism Models: Choosing the Right Model

            Nicolas Lévy and  Pierre L. Roubertoux

2. The Autistic Spectrum Disorders (ASD) : From the Clinics to the Molecular Analysis

            Pierre L. Roubertoux and  Sylvie Tordjman

3. Selecting the Right Species: Practical Information on Organism Models

            Catherine Bartoli, Arnaud Blanchard, Christine Buske, Gwenaelle Collod-Béroud, Laurent Fasano, Christophe Scajola, and Pierre L.  Roubertoux

4. Viewing Animal Models for Tuberous Sclerosis Complex in the Light of Evolution

            Christopher J. Howe, Jaco Serfontein, R. Ellen R. Nisbet, and Petrus J. de Vries

Part II: Modeling Autism Spectrum Disorder at the Brain Level

5. In Vivo Imaging in Mice

            Nathalie Baril, Muriel Roth, and Rym Djouri

6. Invertebrate Models of Synaptic Transmission in Autism Spectrum Disorders

            Manuel Ruiz-Rubio, Fernando Calahorro, and M. Mar Gámez-del-Estal

7. Epigenetic Factors in Normal and Pathological Neuronal Development

            Natacha Broucqsault, Cherif Badja, Marie-Cécile Gaillard, and Frédérique Magdinier

8. Finding Endophenotypes for Autism Spectrum Disorders (ASD): cDNA Microarrays and Brain Transcripts

            Patrice Bourgeois and Pierre Roubertoux

9. Serotonin Disturbance in Mouse Models of Autism Spectrum Disorders

            Kota Tamada and Toru Takumi

Part III: Communication and Social Interactions

10. Communication and Language in Animals

            Gene S. Fisch

11. Social Relationships in Nonhuman Primates: Potential Models of Pervasive Disorders

            Vanessa A.D. Wilson and Alexander Weiss

12. Zebrafish Social Behaviour Testing in Developmental Brain Disorders

            Christine Buske

Part IV: Mouse Models of Autism Spectrum Disorders as Defined by DSM-5R

13. Maintaining Mice for Neurobehavioral Examination

            Pierre L. Roubertoux

14. Deficit in Social Relationships and Reduced Field of Interest in Mice

            Pierre L. Roubertoux , Michèle Carlier, and Sylvie Tordjman

15. Modeling Autism Spectrum Disorders Motor Deficits in Mice

            Pierre L. Roubertoux  and Catherine Bartoli

Part V: Modeling Diseases with a High Prevalence of Autism Spectrum Disorders

16. Neuro-Behavioral Testing of Mouse Models of Rett Syndrome

            Jean-Christophe Roux and Laurent Villard

17. Mouse Models of Tuberous Sclerosis

            Dan Ehninger

18. Use of the Zebrafish Model to Understand Behavioral Disorders Associated with Altered Oxytocin System Development: Implications for Autism and Prader-Willi Syndrome

            Nicole Johnston and Eric Glasgow

19. Epilogue: Perspectives and Caveats

            Pierre L. Roubertoux

Includes cutting-edge methods and protocols for the use of a variety of organism models to explore ASD

Provides both the technical theory and practical aspects needed to achieve successful results in the lab

Contains key notes and implementation advice from the experts