Description
Palladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles, 1st ed. 2020
Springer Theses Series
Author: Yoon Hyung
Language: EnglishSubjects for Palladium and Nickel Catalyzed Transformations Forming...:
Approximative price 158.24 €
In Print (Delivery period: 15 days).
Add to cart the book of Yoon HyungPublication date: 09-2021
212 p. · 15.5x23.5 cm · Paperback
Approximative price 158.24 €
In Print (Delivery period: 15 days).
Add to cart the book of Yoon HyungPublication date: 09-2020
212 p. · 15.5x23.5 cm · Hardback
Description
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This book presents Pd- and Ni-catalyzed transformations generating functionalized heterocycles. Transition metal catalysis is at the forefront of synthetic organic chemistry since it offers new and powerful methods to forge carbon?carbon bonds in high atom- and step-economy.
In Chapter 1, the author describes a Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, known as carboiodination. In the context of the Pd-catalyzed variant, the chapter explores the production of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination. It then discusses Ni-catalyzed reactions to generate oxindoles and an enantioselective variant employing a dual ligand system. Chapter 2 introduces readers to a Pd-catalyzed diastereoselective anion-capture cascade. It also examines diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl nitriles, a method that generates high yields of borylated chromans as a single diastereomer, and highlights its synthetic utility.Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing carbopalladation, C?H activation and ?-system insertion (benzynes and alkynes) to generate spirocycles. It also describes the mechanistic studies performed on these reactions.
Nominated as an outstanding PhD thesis by the University of Toronto, Ontario, Canada
Describes Pd-catalyzed domino reactions in a concise manner
Provides a general overview of C-H activation
Presents a novel Ni-catalyzed carbohalogenation reaction