Description
Parkinson's Disease
Genetics and Pathogenesis
Coordinator: Dawson Ted M.
Language: EnglishSubjects for Parkinson's Disease:
Keywords
Chaperonemediated Autophagy; PINK1 Gene; MPTP Administration; Lewy Bodies; Diffuse Lewy Body Disease; PARKIN Mutations; MPTP Model; Dopaminergic Neurons; MPTP Mouse Model; MAPT Mutation; Substantia Nigra; Complex Iii; MSA; MPTP Toxicity; Sporadic PD; E3 Ligase; E3 Ligase Activity; Tau Isoforms; PARKIN Function; PTEN; Induce Kinase 1; Proteasomal Dysfunction; PARKIN Gene; Parkinson’s Disease; PSP; Nigral Neurons
Publication date: 09-2019
· 15.2x22.9 cm · Paperback
Publication date: 04-2007
450 p. · 15.2x22.9 cm · Hardback
Description
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An authoritative collection of recent breakthroughs in Parkinson's Disease (PD) research, Parkinson?s Disease: Genetics and Pathogenesis spans key findings on the mechanisms of neurodegeneration and the role of specific genes that may lead to improved therapies for PD. The book reviews the major aspects of the disease including motoric and pathologic features, autonomic dysfunction, sleep disorders, and neuropsychiatric manifestations. It also provides an in-depth review of genetic considerations. With contributions by recognized experts on the topic, emphasis is placed on pathogenesis, experimental models, future therapeutic opportunities, and research trends affecting the field.
OVERVIEW. Neuropathology and Staging of Parkinson's Disease. Genetics of Parkinson's Disease. Epidemiology of Parkinson's Disease. Treatment of Parkinson's Disease. GENETICS. Genetics of Alpha-Synuclein. Clinical and Genetic Features of PARKIN-Related Parkinson's Disease. DJ-1 in Parkinson's Disease. PINK1 Parkinsonism. LRRK2. Genetics of Tau in Parkinsonism. Genetic Risk Factors for PD.
PATHOGENESIS. Alpha-Synuclein and Parkinson's Disease. Tau in Parkinson's Disease.
The Role of PARKIN in Parkinson's Disease. Mitochondrial Complex I Deficiency in Parkinson's Disease: A Mechanism for Oxidant-Based Pathogenesis. The Ubiquitin-Proteasome System in Parkinson's Disease. ANIMAL MODELS. Transgenic Models of Alpha-Synucleinopathy. Mouse Models of Recessive Parkinsonism. Drosophila Models of Parkinson's Disease. C. Elegans Models of Parkinson's Disease. The MPTP Model of Parkinson's Disease. Rotenone Model. Drug Trials in Animal Models of PD