Perinatal Stem Cells, 1st ed. 2019
Biology, Manufacturing and Translational Medicine

This book provides a comprehensive introduction to various types of perinatal stem cells. Given their unique regenerative abilities, stem cells offer a promising avenue in the treatment of degenerative diseases or injury.

Currently, the limitations of postnatal cell sources and expanding efficiency may limit autologous stem cell therapies. Although embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be cultured indefinitely ex vivo, and can differentiate into three germ layers, ethical issues, the teratoma formation of ESCs and oncogenic risk of iPSCs are major obstacles to their clinical application. More recently, perinatal stem cells have been isolated from the umbilical cord, Wharton?s Jelly, placenta, amniotic membrane and amniotic fluid, which are normally discarded as medical waste. This book, after describing perinatal stem cells in detail, introduces readers to the various types of perinatal stem cells, addressing their characterization, banking, quality control and stability. Importantly, it also reviews the clinical applications of perinatal stem cells to therapy of diseases. Accordingly, it offers a valuable resource for clinicians, researchers and graduate students alike.

Chapter 1. Introduction of perinatal tissue-derived stem cells.- Chapter 2. The regenerative and reparative potential of amniotic membrane stem cells.- Chapter 3. The stemness of perinatal stem cells.- Chapter 4. Quality Assessment of Umbilical Cord Tissue in Newborn Stem Cell.- Chapter 5. Safety and Genetic Stability of Cultured Perinatal Mesenchymal Stem Cells.- Chapter 6. Therapeutic application of perinatal mesenchymal stem cells in nervous system diseases.- Chapter 7. Umbilical cord blood as a source of novel reagents and therapeutics.- Chapter8. The characteristics and therapeutic application of perinatal mesenchymal stem cells derived exosomes.- Chapter 9. Therapeutic application of perinatal mesenchymal stem cells in diabetes mellitus.- Chapter 10. Perspective of therapeutic angiogenesis using Circulating Endothelial Progenitors from umbilical cord blood.- Chapter 11. Proangiogenic Features of Perinatal Tissue Derived Stem Cells in Cardiovascular Disease Therapy.- Chapter 12. Perinatal Stem Cells in Kidney Regeneration: Current Knowledge and Perspectives.- Chapter 13. Prenatal mesenchymal stem cell secretome and its clinical implication. 

Zhong Chao Han is a professor and director at the State Key Lab of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences; Tsuneo A Takahashi is a visiting professor at the Institute for Frontier Medical Sciences, Kyoto University; Zhibo Han is an associate professor at the State Key Lab of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences.