PET and SPECT in Neurology (2^nd Ed., 2nd ed. 2021)

This book provides a comprehensive overview of the use of PET and SPECT in not only classic neurodegenerative disorders but also cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders, and inflammatory and infectious diseases of the CNS. The new edition has been revised and updated to reflect recent advances and includes additional chapters, for example on the use of artificial intelligence and machine learning in imaging data analysis, the study of brain connectivity using PET and SPECT images, and the role of PET imaging in modulation of brain functioning by deep brain stimulation. The authors are renowned experts whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state of the art compendium will be invaluable for neurologists and radiologists/nuclear medicine specialists and will also be informative for interested general practitioners and geriatricians. Companion volumes on PET and SPECT in psychiatry and in neurobiological systems complete a trilogy.

PART I BASICS: Tracers for Neurology.- Tracer-Kinetic Modeling.- Quantification in Brain SPECT: Noninvasive Cerebral Blood Flow Measurements.- Artificial Intelligence in the Analysis of PET scans of the Human Brain.- MRI/PET Imaging of the Brain.- The Default Network of the Brain.- Analysis of Brain Connectivity using PET, SPECT, and MRI.- PART II DEMENTIA: Neuroimaging Findings in Dementia.- Abeta Imaging.- Imaging of Tau Pathology.- Nicotinic Acetylcholine Receptors.- Neuroimaging Findings in Mild Cognitive Impairment.- Impact of the IWG/Dubois Criteria for AD in Imaging Studies.- Perfusion SPECT in the Diagnosis of AD.- Nuclear Imaging in Frontotemporal Dementia.- Parkinson Dementia: PET Finding.- SPECT/PET Findings in Lewy Body Dementia.- Vascular Dementia.- Value of MIBG in the Differential Diagnosis of Neurodegenerative Disorders.- PART III CEREBROVASCULAR DISORDERS: Perfusion Imaging in Healthy Human Ageing.- Carotid Plaque Imaging with SPECT/CT and PET/CT.- PET in Brain Arteriovenous Malformations and Cerebral Proliferative Angiopathy.- PET Reveals Pathophysiology in Ischemic Stroke.- PART IV MOVEMENT DISORDERS: Parkinson’s Disease.- Computer-Aided Diagnosis of Parkinson Disease, Based on SPECT Scans of the Dopamine Transporter.- PET and SPECT Imaging in Parkinsonian Syndromes.- Amyotrophic Lateral Sclerosis.- PET in Huntington Disease.- PET and SPECT Imaging in Dystonia.- PET and SPECT Imaging in Hyperkinetic Movement Disorders.- Clinical Applications of FP-CIT SPECT.- PART V INFLAMMATORY DISORDERS: PET Imaging of Microglia Activation in Neuropsychiatric Disorders.- PET Imaging in Multiple Sclerosis.- PET and SPECT Imaging of Neurotoxicity.- PET and SPECT in Hepatic and Uremic Encephalopathy.- PART VI EPILEPSY: PET in Epilepsy.- Neuroimaging of Epilepsy.- SISCOM: Subtraction Ictal SPECT Coregistered to MRI.- PART VII TUMORS OF THE NERVOUS SYSTEM: Gliomas.- Neuro-SPECT of Brain Tumors.- Methionine-PET to Distinguish Tumor Recurrence from Radionecrosis.- Brain Metastases of Neuroendocrine Tumors.- PART VIII OTHER SUBJECTS: Anesthesia and PET of the Brain.- Altered States of Consciousness: Coma, Sleep and Hypnosis.- Modulation of CNS Functions by Deep Brain Stimulation: Insights Provided by Molecular Imaging.- Imaging in Pediatric Neurology.

Rudi Dierckx studied medicine and neuropsychiatry at the Free University of Brussels. He was trained as a nuclear medicine physician at the University of Antwerp (1988-1994). Rudi has headed the Department of Nuclear Medicine at the University Hospital of Ghent (Belgium) from 1994 to 2004, and has acquired a Master of Business Administration (MBA) at the Vlerick School of Management in Leuven (2004, cum laude). Since 2005 he is Head of the Department of Nuclear Medicine and Molecular Imaging at University Medical Center Groningen (UMCG) in The Netherlands.  Since 2013, he is also Head of the Medical Imaging Center, and Chairman ad interim of the Department of Radiology at UMCG. His primary research interests are PET studies of the human brain.

Andreas Otte, MD, is a board-certified specialist in Nuclear Medicine and Professor of Biomedical Engineering in the Division of Medical Engineering, Department of Electrical Engineering, Medical Engineering and Computer Science, Offenburg University, Germany. Prof. Otte received his graduate and post-graduate medical education at the University Hospitals Freiburg, Germany, and Basle, Switzerland, and at the Paul Scherrer Research Institute in Villigen, Switzerland. Thereafter he held various leading positions in clinical research with Pfizer in Freiburg, Germany (International Medical Research, Pfizer Global Pharmaceuticals) and at the University Hospital Freiburg. From 2002 to 2009 he was Visiting Professor of Nuclear Medicine in the Medical Faculty of the University of Ghent in Belgium. He took up his present position in 2010. Andreas Otte is the author of many peer-reviewed journal articles and the author or editor/co-editor of a number of books. His research focus is on neurosciences including functional neuroimaging, brain-machine-interfaces, and intelligent neuroprosthetics. Awarded a series of international scientific prizes, he was nominated Editor of the Board of the European Journal ofN