Pharmaceutical solid dispersion technology

* Presents a unified presentation of solid dispersion technology for drugs * Includes recent developments in theory and practice * Aids in new drug formulation and improvement of existing drugs * Provides techniques for improved dissolution rate, sustained release, altered solid-state properties, and improved solubility and stability * Devotes an entire chapter to the use of polymers in solid dispersion The objective of this work is to discuss solid dispersion technology from its practical point of view. Necessary theoretical concepts and mathematical backgrounds are presented concerning dissolution and solid dispersion to assist the reader in understanding the subject matter. An extensive literature search is provided. Areas discussed are the use of phospholipids, polymers, cyclodextrins, and other excipients in solid dispersion. In general, the entire field of solid dispersion is covered in this book making it a one-stop resource on this subject. This book is designed for individuals in the pharmaceutical industry who are solving various formulation problems day to day. This book should also be helpful to individuals in academia and research to gain theoretical and up-to-date developments related to this field.

Preface Historical background of solid dispersionsFundamentals of solid dispersionsTheory of Dissolution Dissolution Methods Definition of Solid Dispersion Classification of Solid Dispersion Methods of Preparing Solid Dispersion Characterization of Solid Dispersion Phospholipids as tools to improve drug dissolutionIntroduction Dissolution Theory Phospholipid as Excipient in Solid Dispersion Dissolution of Drug-Phospholipid Solid Dispersion Mechanism of Dissolution Effect of Phospholipid Composition on Dissolution Effect of Coprecipitating Solvent Application of Drug: Phospholipid Coprecipitates in Controlled Release Stability Conclusions Use of polymers in solid dispersion technologyIntroduction Formulation of Solid Dispersion Polymers Used in Solid Dispersion Polymers and Surface Active Agents Combinations Bioavailability Studies of Polymer-Drug Solid Dispersion Systems Characterization of Polymer: Drug Solid Dispersion Problems Associated with Processing and Stability of Solid Dispersion Cyclodextrins in solid dispersionsIntroduction Structural Features Methods of Drug Incorporation Mechanism of Drug Release Oral Administration of Cyclodextrins Index