Principles of toxicology (2^nd Ed.)

Written by two experienced toxicology lecturers, this book provides a broad-based yet comprehensive introduction to a very diverse subject. Easy-to-read and comprehensive, the book covers this broad and interdisciplinary field from the viewpoint of three different functional levels: molecular and cellular, physiological, and environmental and ecological. This revised second edition expands the diversity of the book while keeping the organizational format that made the first edition a bestseller. It also includes a series of brief case studies illustrating the application of principles to current issues of interest. Each and every chapter has been revised, some significantly updated or rewritten, and three are entirely new. The book contains an extensive cross-referencing system that links all sections and enhances the integration of material. It includes an appendix of selected toxicants describes chemical structure, category of use. These features combine to make finding specific information quick and easy. The highly readable format provides a uniform, consistent presentation of information. See what's new in the second edition: New material in the areas of comparative toxicology and the role of biotransformation in human disease. Coverage of the role of genomics in toxicology. Advances in understanding of carcinogenesis, particularly roles of oncogenes and tumor suppressor genes. New information on excitotoxicology and the potential role of toxicants in neurological disease. New chapter on the role of toxicology in pharmacology, focusing on drug development. New chapter on the role of toxicology in forensic investigations.

Measuring Toxicity and Assessing Risk. Toxicokinetics. Biotransformation. Cellular Sites of Action. Mechanisms of Cell Death. Toxicology and Genomics. Carcinogenesis. Reproductive Toxicology and Teratology. Respiratory Toxicology. Cardiovascular Toxicology. Neurotoxicology. Hepatic Toxicology. Renal Toxicology. Immunotoxicology. Ecological Toxicology. Pharmacology, Toxicology, and Drug Development. Toxicology and Forensics. Air Pollution. Water Pollution. Toxic Wastes.