Rectal Cancer, 2010
International Perspectives on Multimodality Management
Current Clinical Oncology Series

Rectal Cancer: International Perspectives on Multimodality Management is a timely analysis of the diagnosis, staging, pathology, and therapy of cancer of the rectum. This book is intended as a useful resource for physicians, scientists, medical students, and allied health personnel in the disciplines of radiology, gastroenterology, surgical oncology, medical onc- ogy, radiation oncology, and pathology. Renowned contributors from different medical d- ciplines have written their chapters in a thoughtful, provocative, and visual fashion. Importantly, these chapters highlight the controversies in the diagnostic, staging, and the- peutic management of patients with rectal cancer while providing practical management recommendations. This book is divided into 18 chapters. Early chapters address the diagnosis and staging of rectal cancer, highlighting the critical role of contemporary imaging in guiding treatment. The remaining chapters focus on the multimodality management of rectal cancer from the vantage points of surgery, pathology, chemotherapy, and radiation therapy. The major dev- opments in surgery are reviewed first, including contemporary roles of local excision, total mesorectal excision, lateral pelvic lymph node dissection, organ preservation approaches, as well as the management of advanced, recurrent, and metastatic disease. Following is a ch- ter describing the pathologic evaluation of rectal cancer specimens, with emphasis on proper methodology and its clinical relevance to overall disease management. The final chapters review the contemporary roles of chemotherapy (including with radiation therapy, adjuvant and neoadjuvant settings without radiation therapy, as well as in metastatic disease) as well as radiation therapy (including adjuvant and neoadjuvant approaches, short vs.

Clinical Staging: Endoscopic Techniques.- Clinical Staging: CT and MRI.- Local Excision.- Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection.- Abdominoperineal Resection, Low Anterior Resection, and Beyond.- T4 and Recurrent Rectal Cancer.- Surgical Management of Pulmonary Metastases.- Surgical and Ablative Management of Liver Metastases.- Surgical Pathology.- Chemotherapy: Concurrent Delivery with Radiation Therapy.- Chemotherapy: Adjuvant and Neoadjuvant Approaches.- Chemotherapy: Metastatic Disease.- Radiation Therapy: Adjuvant vs. Neoadjuvant Therapy.- Radiation Therapy: Short Versus Long Course.- Chemoradiation Therapy: Nonoperative Approaches.- Contact X-Ray Therapy.- High-Dose-Rate Preoperative Endorectal Brachytherapy for Patients with Rectal Cancer.- Radiation Therapy: Technical Innovations.

Presents state-of-the-art knowledge of biology, genetics, staging, and treatment Attention to outcomes and quality of life of survivors Provides the most current examination of US and European clinical trials Covers medical, surgical, and radiation therapies Written by key international opinion leaders Includes supplementary material: sn.pub/extras