Description
Stereoselective Syntheses of Tetrahydropyrans, Softcover reprint of the original 1st ed. 2014
Applications to the Synthesis of (+)-Leucascandrolide A, (+)-Dactylolide and (±)-Diospongin A
Springer Theses Series
Language: EnglishSubjects for Stereoselective Syntheses of Tetrahydropyrans:
Stereoselective Syntheses of Tetrahydropyrans
Publication date: 09-2016
Support: Print on demand
Publication date: 09-2016
Support: Print on demand
Stereoselective Syntheses of Tetrahydropyrans
Publication date: 03-2014
184 p. · 15.5x23.5 cm · Hardback
Publication date: 03-2014
184 p. · 15.5x23.5 cm · Hardback
Description
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In his thesis, Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans (THP). Readers gain insight into the new methods Lee employs for the synthesis of biologically interesting natural products including (+)-leucascandrolide A, (+)-dactylolide, and (±)diospongin A. The reactions Lee investigates are applicable to a broad range of substrates and proceed with excellent stereoselectivity. Moreover, the methodologies allow the synthesis of a wide range of THP-containing compounds. The development of reactions, such as those discussed by Lee, has the potential to impact natural product synthesis, pharmaceutical development and chemical biology.
Introduction.- Significance.- General Approaches to the Synthesis of Substituted Tetrahydropyrans.- Stereoselective Synthesis of Tetrahydropyrans via Tandem and Organocatalytic Oxa-Conjugate Addition Reactions.- Introduction.- Preliminary Study.- Result and Discussion.- Synthesis of 4-Hydroxy-2,6-cis-Tetrahydropyrans via Tandem Cross-Metathesis/Thermal SN2′ Reaction.
Nominated as an outstanding Ph.D. thesis by Duke University, USA Pursues a clearly structured and easy-to-follow methodology Provides straightforward figures of target molecules Includes easy-to-find references for further reading
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