Description
Structural Glycobiology
Coordinators: Yuriev Elizabeth, Ramsland Paul A.
Language: English
Subjects for Structural Glycobiology:
Keywords
Sialic Acid; Glycan Structures; Biomacromolecules; Glycan Microarray; Three-Dimensional Structural; Glycan Shield; Carbohydrates; Protein Carbohydrate Interactions; Structural Glycobiology; PDB Id; Van Der Waals; Glycan Release; Sample Preparation; Natural Glycans; SAXS Data; STD NMR; NMR Titration Experiment; Chemical Shift Mapping; Em Map; NOESY Experiment; HIV-1 Gp120; Avian Receptor; Electron Cryomicroscopy; cryoEM; 1H-15N HSQC Spectrum; Glycomic Analysis; Reactive Site Loop; H1 HA; H3 HA
328 p. · 15.6x23.4 cm · Paperback
Description
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Structural Glycobiology covers the experimental, theoretical, and alternative technologies used in the study of the structural basis for the diverse biological roles of carbohydrates. The book overviews the application of specialized technologies to the study of carbohydrates in biology, reviews relevant and current research in the field, and is illustrated throughout by specific examples of how research investigations have yielded key structural and associated biological data on carbohydrates and glycolipids. In particular, the book focuses on:
- X-ray crystallography and small-angle scattering, NMR, and cryo-electron microscopy techniques
- Theoretical (modeling-based) approaches, such as molecular mechanics, molecular dynamics, free energy calculations, and carbohydrate docking
- Alternative techniques for yielding structural information on carbohydrates from complex biological samples
- Carbohydrates in medicine, specifically in areas that have been directly impacted by our understanding of the structural role of carbohydrates in immune recognition: cancer, organ transplantation, and infection
Experimental Techniques to Determine Three-Dimensional Structures: Crystallography and Small-Angle Scattering of Carbohydrate–Protein Complexes and Glycoproteins. Nuclear Magnetic Resonance Studies of Carbohydrate–Protein Interactions. Electron Cryomicroscopy of Large Glycoprotein Assemblies. Theoretical/Modeling Techniques to Predict Three-Dimensional Structures: Protein–Carbohydrate Interactions: Computational Aspects. Docking of Carbohydrates into Protein Binding Sites. Alternative Approaches for Yielding Detailed Structural Information: Mass Spectrometry for Glycomics Analysis of N- and O-Linked Glycoproteins. Glycan-Based Arrays for Determining Specificity of Carbohydrate-Binding Proteins. Carbohydrates in Medicine: Structural Glycobiology: Applications in Cancer Research. Structural Glycobiology: Applications in Organ Transplantation. Structural Glycobiology: Applications in Viral Infection. Developing Drugs from Sugars Current State of Glycosaminoglycan-Derived Therapeutics.
Elizabeth Yuriev is with the Monash Institute for Pharmaceutical Sciences at Monash University, Australia. Paul A. Ramsland is with the Centre for Immunology at the Burnet Institute in Melbourne, Australia.