The Identification of the CF (Cystic Fibrosis) Gene, Softcover reprint of the original 1st ed. 1991 Recent Progress and New Research Strategies Advances in Experimental Medicine and Biology Series, Vol. 290

Proceedings of an international workshop held in Sestri Levante (Genoa), Italy, April 9--11, 1990

Cystic Fibrosis — A Strategy for the Future.- Molecular Genetics of Cystic Fibrosis.- The CF Gene Product as a Member of a Membrane Transporter (TM6-NBF) Super Family.- Genetic Analysis of Cystic Fibrosis.- Molecular and Genetic Analyses at the CF Locus.- Identification of Cystic Fibrosis Mutations.- Mutation Analysis for Cystic Fibrosis in a North American Population.- Toward a Geographical History of the Predominant and Secondary Mutations in Europe.- Origin and Diffusion of the Major CF Mutation in Europe.- Present State of DNA-Diagnosis for Cystic Fibrosis and Attitudes Concerning a Heterozygote Screening in the GDR.- Pros and Cons of Neonatal Screening for Cystic Fibrosis.- Genotype-Phenotype Correlations in Cystic Fibrosis Patients.- Ion Transport in Normal and CF Airway Epithelia.- Aerosolized Amiloride as Treatment of Cystic Fibrosis Lung Disease: A Pilot Study.- Some Properties of Sodium and Chloride Channels in Respiratory Epithelia of CF- and Non-CF-Patients.- Roles of Ca and cAMP on Cl Channel Activity in Cystic Fibrosis Sweat Clear Cells as Studied by Microsuperfusion and Cell Volume Analysis.- Regulation of Absorption in the Human Sweat Duct.- Altered Biochemical Regulation of Secretion in Cystic Fibrosis Epithelial Cells.- Chloride Ion Transport in Transformed Normal and Cystic Fibrosis Epithelial Cells.- Conductance Pathways Involved in Chloride Secretion and Their Regulation.- Regulation of Epithelial Chloride Channels: Roles of Protein Kinases and Arachidonic Acid.- Cytosolic Inhibition and Excision Activation of Epithelial Chloride Channels.- Purification of the Epithelial Cl Channel.- Regulation of Expression of CFTR in Human Intestinal Epithelial Cells.- Cystic Fibrosis, the CFTR, and Rectifying Cl- Channels.- Regulation of Ion Conductance inHuman Skin Fibroblasts.- Chloride Transport in the Cystic Fibrosis Enterocyte.- Chloride Transport Pathways in Human Keratinocytes.- A Chloride Conductance Evoked by Hypotonic Shock in Epithelial Cells.- Regulation of Lymphocyte Chloride Channels.- Guanine Nucleotide Binding Proteins Regulate Epithelial Na+ Channels.- Attitudes of Parents of Cystic Fibrosis Children Towards Neonatal Screening and Antenatal Diagnosis.- DNA Analysis in CF Families by Biotinylated Probes and Polymerase Chain Reaction Technique.- Prevalence of the Major Mutation of the CF Gene in Belgian Patients.- Cystic Fibrosis in the Sicilian Population: Linkage Disequilibrium and Prenatal Diagnosis by Polimerase Chain Reaction.- Study of Reconstitution of the Rabbit Parotid Na+/K+/2Cl-Cotransporter.- Human Placental Membrane Vesicles as Models for Investigation of Cystic Fibrosis.- The DeltaF508 Mutation in Israeli CF Families.- The DeltaF508-Deletion in 99 CF Patients of Switzerland.- The Prevalence of the Deletion F508 in a Belgian Cystic Fibrosis Population.- Cystic Fibrosis Delta F508 Mutation in a French Population.- Frequency of the Delta-F508 Mutation and Flanking Marker Haplotypes at the Cystic Fibrosis Locus from 167 Czech Families.- The Response of Chloride Transport to Cyclic AMP, Calcium and Hypotonic Shock in Normal and Cystic Fibrosis Fibroblasts.- 2D-Electrophoresis of Mitochondrial Proteins from Cystic Fibrosis Patients.- Frequency of Cystic Fibrosis Mutations and Associated Haplotype Distribution in Slovak CF Patients.- Frequency of Cystic Fibrosis Mutations Among Italian Patients.- Cultured Human Placental Trophoblasts as Models for Investigating Defective Regulation of Chloride Transport and Protein Secretion in Cystic Fibrosis.- A Deletion Mutation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Locus: DeltaI507.- DNA Technology for Prenatal Diagnosis of Cystic Fibrosis in Italy.- Incidence of Cystic Fibrosis at the Faroe Islands.