Description
Thin Layer Chromatography in Chiral Separations and Analysis
Coordinators: Kowalska Teresa, Sherma Joseph
Language: EnglishSubjects for Thin Layer Chromatography in Chiral Separations and Analysis:
Keywords
Chiral Selector; Micro-crystalline Cellulose; chirality; Chiral Solvating Agent; thin layer chromatography; Mobile Phase; enantiomers separation; CSPs; Chiral Separation; Chiral Mobile Phase Additives; Chiral Recognition; Marfey’s Reagent; Keto Enol Tautomerism; Silica Gel Plates; Diastereomeric Complexes; TLC Separation; Amino Acid Enantiomers; Planar Chromatography; CLEC; Chiral Mobile Phase; Enantiomeric Separation; TLC Plate; Silanized Silica Gel; Diastereomeric Salts; Normal Phase Tlc; Racemic Amino Acids; HPTLC Plate; Octan-3 Carboxylic Acid
Publication date: 12-2019
· 15.2x22.9 cm · Paperback
Publication date: 06-2007
440 p. · 15.2x22.9 cm · Hardback
Description
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Thin layer chromatography (TLC) is well suited for performing enantioseparations for research as well as larger-scale applications. A fast, inexpensive, and versatile separation technique, there are many practical considerations that contribute to its effectiveness. Thin Layer Chromatography in Chiral Separations and Analysis is the first book to focus solely on the theory, capabilities, and applications of TLC for direct and indirect enantioseparations.
The first part of the book examines the fundamental principles of chirality and TLC. It describes the necessary materials, laboratory equipment, procedures, and strategies for the separation, quantification, isolation, and analysis of chiral compounds. The second part evaluates the real-world enantioseparations and densitometric analyses. Emphasizing pharmaceutical applications, the book discusses chiral separation mechanisms and methods for analyzing the chiral purity of diastereoisomers, amino acids, beta-blockers, and NSAIDS. Topics also include commercial stationary phases and chiral modifiers of mobile phases.
Thin Layer Chromatography in Chiral Separations and Analysis presents a unified perspective of theory and experimental details underlying the collective developments in the field. The book offers scientists in a variety of disciplines and levels of expertise a complete guide to understanding the current and potential applications of chiral TLC.
Introduction. Chirality. Commercial Stationary Phases for Enantioseparations. Planar Chromatographic Enantioseparations on Non-commercial CSPs. Planar Chromatographic Enantioseparations on Non-Commercial CCPs. Chiral Modifiers of Mobile Phases. An Overview of the Chiral Separation Mechanisms. Separation of Diastereoisomers by means of TLC. Selected Bottlenecks of Densitometric Detection with Chiral Analytes. Chirality of Pharmaceutical Product Racemates. Chiral Separation of the Selected β-blockers. Chiral Separation of Aminoacid Enantiomers. Chiral Separation of NSAIDs. Determination of Components in Selected Drug Racemates. Chiral Separations using Marfey’s Reagent.