Tumor Microenvironment and Cellular Stress, 2014 Signaling, Metabolism, Imaging, and Therapeutic Targets Advances in Experimental Medicine and Biology Series, Vol. 772

Introduction.- Hypoxia and metabolism in cancer.- Hypoxia and Regulation of Cancer Cell Stemness.- Hypoxia-mediated metastasis.- Escape Mechanisms from Antiangiogenic Therapy: An Immune Cell’s Perspective.- Hypoxic VDAC1: a potential mitochondrial marker for cancer therapy.- Hypoxia directed drug strategies to target the tumor microenvironment.- Radiotherapy and the Tumor Microenvironment: Mutual Influence and Clinical Implications.- Autophagy and cell death to target cancer cells: exploiting synthetic lethality as cancer therapeutic.- Intratumoral Hypoxia as the Genesis of Genetic Instability and Clinical Prognosis in Prostate Cancer.- miR-210: Fine-Tuning the Hypoxic Response.- The role of complement in tumor growth.- Imaging angiogenesis, inflammation and metastasis in the tumor microenvironment with magnetic resonance imaging.- Index.

Constantinos Koumenis, Ph.D. is an Associate Professor, Vice Chair and Research Division Director and Co-Leader, Radiation Biology & Imaging Program at the University of Pennsylvania, School of Medicine. Amato Giacca,Ph.D., is a Professor and Director of the Department of Radiation Oncology, Leader of Radation Biology and Molecular Therapeutics Program at the Stanford Cancer Center. Ester Hammond Ph.D., is a Junior Group Leader at Gray Institute for Radiation Oncology and Biology at Oxford University.

Explores significant advances in understanding the genetic determinants of stress responses? Discusses various cellular and animal models of tumor microenvironment study Features novel targets for imaging and therapeutic intervention