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Ultrafiltration for Bioprocessing Woodhead Publishing Series in Biomedicine Series

Langue : Anglais

Auteur :

Couverture de l’ouvrage Ultrafiltration for Bioprocessing
Ultrafiltration for Bioprocessing is key reading for all those involved in the biotechnology and biopharmaceutical areas. Written by a leading worker in the area, it includes many practical applications and case studies in the key process of ultrafiltration (UF), which is used in almost every bioprocess.
FundamentalsMembranesModulesProcess configurationsProcessing; RecoveryCleanupManufacturing systemsTrouble shooting
Herb Lutz has degrees in chemistry and chemical engineering from the University of California, Santa Barbara and attended graduate school in Business and Chemical Engineering at MIT. He has worked in the area of separations and purification for 30 years. Herb is a principal consulting engineer with Millipore Corporation and currently focuses on the development, validatation, scale-up and trouble-shooting of new downstream purification applications such as virus clearance, sterile filtration, clarification, tangential flow filtration, chromatographic purification, and membrane adsorbers. He has also worked in product management, and strategic marketing. As a thought leader in the field, Herb is a frequent conference presenter, chair and has assisted in organizing several conferences. He has published several book chapters including the Membrane Separation Section of Perry’s Chemical Engineer’s Handbook, holds a filtration patent, is on the scientific advisory board for Biopharm International, and has published in the areas of scaling, ultrafiltration, membrane adsorption, integrity testing and virus clearance. Mr. Lutz has taught membrane applications for Millipore, for the ASME Bioprocess course, and for the Society for Bioprocessing Professionals.
  • Focuses on ultrafiltration for biopharmaceuticals—other books look at general ultrafiltration or general biopharmaceuticals
  • A mix of theory and practical applications—other books tend to be more theory-oriented
  • Addresses the main issues encountered in development and scale-up through recommendations and case studies

Date de parution :

Ouvrage de 244 p.

15.5x23.2 cm

Disponible chez l'éditeur (délai d'approvisionnement : 14 jours).

160,74 €

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Thèmes d’Ultrafiltration for Bioprocessing :

Mots-clés :

Abcor; acceptable range; adsorbed solutes; aggregation; alarm range; AMICON; back transport; batch concentration; batch diafiltration; batch ultrafiltration; blank run; blowdown; Brownian diffusion; buffer equilibration; Cwall; CAPA; cassette; casting; characterization studies; charged solute sieving; cleaning; cleaning/reuse studies; components; configurations; constant volume diafiltration; continuous diafiltration; continuous ultrafiltration; control; corrective action; cross-flow filtration; dead leg; depolarization; design space; diafiltration; diavolumes N; discontinuous diafiltration; edge of failure; extractables; failure modes; fed-batch concentration; filtrate; flushing; flux; formulation; fractionation; friction factor; future developments; high concentration formulation; high feed channel resistance; high performance TFF; history; hollow fibre; inertial lift; instrumentation; integral modules; integrity test failure; integrity testing; IQ; layout; low NWP; low process permeability; low yields; mass flux; membrane ratings; membrane selection; membrane specifications; module installation; module selection; morphology; NFF; NMWL; normal operating range; NWP; operating parameter selection; optimized diafiltration strategy; OQ; osmotic pressure; passage; performance attributes; permeability; permeate; piping; plate-and-frame; plug flow flush; polarization; polarization layer; poor excipient clearance; pores; porous channel flow; porous channel mass transfer coefficient; PQ; preventive action; process parameters; processing; pump; QbD; quality attributes; quality by design; recirculation recovery; recovery