Description
Calcitonin Gene-Related Peptide (CGRP) Mechanisms, 1st ed. 2019
Focus on Migraine
Handbook of Experimental Pharmacology Series, Vol. 255
Coordinators: Brain Susan D., Geppetti Pierangelo
Language: EnglishSubjects for Calcitonin Gene-Related Peptide (CGRP) Mechanisms:
Calcitonin Gene-Related Peptide (CGRP) Mechanisms
Publication date: 09-2020
Support: Print on demand
Publication date: 09-2020
Support: Print on demand
Calcitonin Gene-Related Peptide (CGRP) Mechanisms
Publication date: 09-2019
Support: Print on demand
Publication date: 09-2019
Support: Print on demand
Description
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This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.
1. CGRP Discovery and Timeline.- 2. CGRP Receptor Biology: Is There More Than One Receptor?.- 3. The Structure of the CGRP and Related Receptors.- 4. CGRP Receptor Signalling Pathways.- 5. Pathways of CGRP Release from Primary Sensory Neurons.- 6. CGRP in Animal Models of Migraine.- 7. CGRP in Human Models of Migraine.- 8. Role of CGRP in Migraine.- 9. Understanding CGRP and Cardiovascular Risk.- 10. CGRP and Painful Pathologies other than Headache.- 11. Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.
Provides a thorough review of the key recent research into the role of CGRP in health and disease
Enables and enriches understanding of CGRP in migraine pathophysiology
Provides a full update of the latest therapeutic perspectives and clinical advancements with potential therapeutic agents that block the actions of CGRP
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