Description
G Protein-Coupled Receptor Kinases, 1st ed. 2016
Methods in Pharmacology and Toxicology Series
Language: EnglishSubject for G Protein-Coupled Receptor Kinases:
Publication date: 07-2016
Support: Print on demand
Publication date: 05-2018
Support: Print on demand
Description
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Part I: Introduction
1. G Protein-Coupled Receptor Kinases (GRKs) History: Evolution and Discovery
Vsevolod V. Gurevich and Eugenia V. Gurevich
Part II: GRK Structure, Mechanisms of Activation, and Interaction with GPCRs
2. Structure and Function of G Protein-Coupled Receptor Kinases 1 and 7
Tivadar Orban and Krzysztof Palczewski
3. Visual G Protein-Coupled Receptor Kinases
Chih-Chun Hsu and Ching-Kang Jason Chen
4. Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily
Tyler S. Beyett, Sumit J. Bandekar, and John J.G. Tesmer
5. “Barcode” and Differential Effects of GPCR Phosphorylation by Different GRKs
Kunhong Xiao and Hongda Liu
Part III: GRKs in Cell Signaling
6. Cell-Type Specific GRK2 Interactomes: Physiopathological Implications
Federico Mayor, Jr., Rocío Vila-Bedmar, Laura Nogués, Marta Cruces-Sande, Elisa Lucas, Verónica Rivas, Clara Reglero, Petronila Penela, and Cristina Murga
7. Differential Regulation of IGF-1 and Insulin Signaling by GRKs
Leonard Girnita, Ada Girnita, and Caitrin Crudden
8. Differential Control of Potassium Channel Activity by GRK2
Adi Raveh, Liora Guy-David, and Eitan Reuveny
Part IV: Physiological and Pathophysiological Mechanisms Regulated by GRKs
9. Critical Role of GRK2 in the Prevention of Chronic Pain
Faiza Baameur, Pooja Singhmar, Cobi J. Heijnen, and Annemieke Kavelaars
10. Roles of GRK Dysfunction in Alzheimer’s Pathogenesis
William Z. Suo
11. Regulation of Dopamine-Dependent Behaviors by G Protein-Coupled Receptor Kinases
Eugenia V. Gurevich, Raul R. Gainetdinov, and Vsevolod V. Gurevich
12. G Protein-Coupled Receptors and Their Kinases in Cardiac Regulation
Alessandro Cannavo, Claudio de Lucia, and Walter J. Koch
13. GRK Roles in C. elegans
Jordan F. Wood and Denise M. Ferkey
14. Evolutionarily Conserved Role of G Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathway
Dominic Maier and David R. Hipfner
Features detailed examinations of known GRK-dependent mechanisms, both associated with GPCR functions and receptor-independent
Covers a wide range of studies from invertebrates to humans
Provides practical advice from the experts on how to continue research on GRKs
Includes supplementary material: sn.pub/extras