Integrin Targeting Systems for Tumor Diagnosis and Therapy, 1st ed. 2018
Methods in Pharmacology and Toxicology Series

Coordinator: Patsenker Eleonora

Language: Anglais
Cover of the book Integrin Targeting Systems for Tumor Diagnosis and Therapy

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· 17.8x25.4 cm · Hardback
This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular. The chapters consecutively describe the tools for structural analysis, identification and detection of integrins as biomarkers, and include thorough laboratory and clinically-related methods on different strategies for generation, synthesis and evaluation of probes, carriers, peptides or small particles for integrin targeting, imaging, and drug delivery. As part of the Methods in Pharmacology and Toxicology series, this book contains the practical details that are invaluable in the laboratory. 
Authoritative and advantageous, Integrin Targeting Systems for Tumor Diagnosis and Therapy serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research.
1. Tumor Targeting by RGD-Grafted PLGA-Based Nanotheranostics Loaded with Paclitaxel and Superparamagnetic Iron Oxides

            Fabienne Danhier, Pierre Danhier, Nathalie Schleich, Chrystelle Po, S. Laurentc, P. Sibret, C. Jérôme, V. Poucelle, Bernard Gallez, and Véronique Préat


2. Fabrication of cRGD Conjugated Dual Responsive Micelles to Target αvβ5 Integrin Overexpressed Cancer

            Huacheng He, Remant Bahadur K.C., and Peisheng Xu


3. Copper-Free Click Chemistry Modification of Nanovectors for Integrin Targeted Cancer Therapy

            Chang-Fang Wang and Hélder A. Santos


4. Preparation, Characterization, and In Vitro and In Vivo Evaluation of PEGylated Liposomal D

oxorubicin Modified with Different cRGD Peptides

            Mohamadreza Amin and Mahmoud Reza Jaafari


5. Preparation of Heterobivalent and Multivalent Radiopharmarmaceuticals to Target Tumors Over-Expressing Integrins

            Guillermina Ferro-Flores, Blanca Ocampo-García, Clara Santos-Cuevas, Nallely Jiménez‑Mancilla, Myrna Luna-Gutiérrez, Flor de M. Ramírez, Enrique Morales-Avila, Luis M. De León-Rodríguez, and Erika Azorín-Vega


6. 177Lu Labeled RGD-BBN Peptide for Targeting Prostate Cancer

            Lei Jiang and Zhen Cheng


7. Integrin-Mediated Targeting of Liposomally-Bound siRNAs to Tumor Vasculatures

            Poulami Ma

jumder and Arabinda Chaudhuri


8. Integrin αvβ3-Targeted Optical Imaging with Metal Oxide Nanomaterials: Focusing on Zinc Oxide

            Hao Hong and Weibo Cai


9. Integrin Targeting Using RGD-Based Peptide Amphiphiles

            Poonam Saraf, Xiaoling Li, and Bhaskara Jasti


10. Cyclic-RGDfK-Directed Docetaxel Loaded Nanomicelles for Angiogenic Tumor Targeting

            Hitesh Kulhari, Deep Pooja, Shweta Shrivastava, T. Srinivasa Reddy, Ayan Kumar Barui, Chitta Ranjan Patra, Naidu V.G.M., David J. Adams, and Ramakrishna Sistla


11. Targeting Glioma Cancer Cells with Fluorescent Nanodiamonds Via Integrin Receptors


bsp;       Jitka Neburkova, Miroslav Hajek, Ivan Rehor, Jiri Schimer, Frantisek Sedlak, Jan Stursa, Martin Hruby, and Petr Cigler


12. NIR Imaging-Guided Photothermal Therapy by cRGD-Conjugated Solid Lipid Nanoparticles Encapsulating IR-780

            Ye Kuang, Kunchi Zhang, Min Liu, and Renjun Pei


13. Synergistic Active Targeting to B16F10 Tumors by αvβ3/CD44-Targeted Nanoparticles Loaded with Docetaxel

            Sanjun Shi

Features techniques and methodologies to facilitate integrin biology research and target identification

Examines approaches for the treatment of multiple organ diseases, with a focus on cancer

Includes practical advice to ensure success in the lab