Description
Mechanisms of Drug Resistance in Cancer Therapy, 1st ed. 2018
Handbook of Experimental Pharmacology Series, Vol. 249
Coordinators: Mandalà Mario, Romano Emanuela
Language: EnglishSubjects for Mechanisms of Drug Resistance in Cancer Therapy:
Support: Print on demand
Description
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A major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient stratification and tailor treatments. It offers to the readers an updated overview on the possible reasons of failure of new and promising therapeutic opportunities.
Gives an updated overview on the possible reasons of failure of new and promising therapeutic opportunities
Provides extensive discussions of issues including pharmacodynamic and pharmacokinetic mechanisms of resistance, alterations in the drug target, activation of prosurvival pathways, ineffective induction of cell death, and plasticity of microenvironment
Covers the diverse perspectives of basic scientists, clinical pharmacologists and clinicians