Target Organ Toxicology in Caenorhabditis elegans, 1st ed. 2019

This book introduces readers to intestinal and epidermal barriers, and to toxicity induction of environmental toxicants or stresses in the intestine, epidermis, neurons, muscle, and reproductive organs in Caenorhabditis elegans. In addition, it discusses the protective responses of various organs and nematodes? avoidance behaviour with regard to environmental toxicants or stresses. The intestinal, epidermal, neuronal, and germline signalling pathways required for the regulation of toxicity of environmental toxicants or stresses are also introduced and discussed.

As a classic model animal with well-described genetic and developmental backgrounds, the nematode Caenorhabditis elegans has been successfully and widely used in both toxicity assessments and toxicological studies on various environmental toxicants and stresses. Once exposure to certain environmental toxicants has occurred, the toxicants can enter into the primary targeted organs (such as intestinal cells), and even be translocated into secondary targeted organs (such as reproductive organs and neurons). Based on related available data, this book provides a systematic understanding of target organ toxicology in C. elegans.

Protective Responses of Different Organs to Environmental Toxicants or Stresses.- Avoidance Behaviour of Nematodes to Environmental Toxicants or Stresses.- Intestinal Barrier for Nematodes against Toxicity of Environmental Toxicants or Stresses.- Epidermal Barrier for Nematodes against Toxicity of Environmental Toxicants or Stresses.- Toxicity Induction in Intestine and Epidermis in Nematodes Exposed to Environmental Toxicants or Stresses.- Toxicity Induction in Neurons and Muscle in Nematodes Exposed to Environmental Toxicants or Stresses.- Reproductive Toxicity Induction in Nematodes Exposed to Environmental Toxicants or Stresses.- Intestinal Signalling Pathways Required for the Regulation of Toxicity of Environmental Toxicants or Stresses.- Epidermal Signalling Pathways Required for the Regulation of Toxicity of Environmental Toxicants or Stresses.- Neuronal Signalling Pathways Required for the Regulation of Toxicity of Environmental Toxicants or Stresses.- Germline Signalling Pathways Required for the Regulation of Toxicity of Environmental Toxicants or Stresses.

Dr. Dayong Wang is a professor at the Medical School, Southeast University, China. He obtained his Ph.D. from Peking University in 2001 and completed his post-doctoral training at the University of Toronto from 2002 to 2004. His research focuses on toxicology and pathology using Caenorhabditis elegans as a model animal, fields in which he has published more than 160 research articles.

Broadens readers’ understanding to the toxicology in C. elegans

Provides a comprehensive introduction to target organ toxicology in C. elegans

Focusing on the intestinal and epidermal barriers and toxicity induction of environmental toxicants or stresses in the intestine, epidermis, neurons, muscle, and reproductive organs