Handbook of Molecular Force Spectroscopy, Softcover reprint of hardcover 1st ed. 2008

Researchers in academia and industry who are interested in techniques for measuring intermolecular forces will find this an essential text. It presents a review of modern force spectroscopy, including fundamentals of intermolecular forces, technical aspects of the force measurements, and practical applications. The handbook begins with a review of the fundamental physics of loading single and multiple chemical bonds on the nanometer scale. It contains a discussion of thermodynamic and kinetic models of binding forces and dissipation effects in nanoscale molecular contacts, covers practical aspects of modern single-molecule level techniques, and concludes with applications of force spectroscopy to chemical and biological processes. Computer modeling of force spectroscopy experiments is also addressed.

Surface force apparatus measurements of molecular forces in biological adhesion
(Deborah Leckband, Univ. of Illinois, Urbana-Champaign)

Force spectroscopy with optical and magnetic tweezers (Richard Conroy, Harvard University)

Chemical Force Microscopy 1: Nanoscale probing of fundamental chemical interactions (Aleksandr Noy, LLNL, Dmitry V. Vezenov, Harvard University, and Charles M. Lieber, Harvard University)

Chemical Force Microscopy 2: Interactions in complex molecular assemblies (Dmitry V. Vezenov, Harvard University, Aleksandr Noy, LLNL, and Charles M. Lieber, Harvard University)

Dynamic force spectroscopy with the atomic force microscope (Phil Williams,University of Nottingham)

Simulation in force spectroscopy (David L. Patrick, Western Washington University)

Probe tip functionalization: applications to chemical force microscopy (Craig D. Blanchard, Albert Loui, and Timothy V. Ratto, LLNL)

The dynamical response of proteins under force (Kirstine L. Anderson, Sheena E. Radford, D. Alastair Smith, and David J. Brockwell, University of Leeds)

Counting and breaking single bonds: Dynamic force spectroscopy in tethered single molecule systems (Todd A. Sulchek, Raymond W. Friddle, and Aleksandr Noy, LLNL)

Direct mapping of intermolecular interaction potentials (Paul D. Ashby, MIT)

Provides an authoritative guide to planning, understanding, and analyzing modern molecular force spectroscopy experiments

Presents state-of-the-art research at the nanoscale and single-molecule levels with an emphasis on biophysics

Addresses computer modeling of force spectroscopy experiments

Includes supplementary material: sn.pub/extras