Description
Recent Trends in Carbohydrate Chemistry
Synthesis and Biomedical Applications of Glycans and Glycoconjugates
Coordinators: Rauter Amélia Pilar, Christensen Bjørn E., Somsák László, Kosma Paul, Adamo Roberto
Language: EnglishSubject for Recent Trends in Carbohydrate Chemistry:
Keywords
Aminoarabinose; Antifungal glycoconjugate vaccines; Binary glycosyl phosphodiester; Burkholderia lipid A; Capsular polysaccharide; Carrier proteins; Conjugation chemistry; Francisella lipid A; Fungal pathogens; Glycoconjugate; Glycoconjugate vaccines; Glycolipids; Glycosylation; Heptose; Innate immunity; Kdo; Lipopolysaccharide; Nuclear magnetic resonance spectroscopy; O-antigen; Oligosaccharide; Physicochemical characterization; Quality control; Synthesis; Synthetic carbohydrate; TLR4/MD-2
438 p. · 15x22.8 cm · Paperback
Description
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Recent Trends in Carbohydrate Chemistry: Synthesis and Biomedical Applications of Glycans and Glycoconjugates covers biomedically relevant bacterial cell wall carbohydrates including recent findings on biosynthetic aspects, advances in the chemical assembly of bacterial lipopolysaccharide fragments and teichoic acids, and modern NMR approaches to unravel structural details. The first part introduces and provides the relevant background for synthetic glycoconjugate vaccines. The second section focuses on synthetic carbohydrate-based vaccines of therapeutic potential that are licensed or under development.
This second volume of Recent Trends in Carbohydrate Chemistry is ideal for researchers working as synthetic organic chemists, as well as those interested in glycoconjugation, protein chemists, immunologists, and microbiologists, in academia as well as in industry.
I. Advances in chemical synthesis and biosynthesis of bacterial glycans 1. Prokaryotes: Sweet proteins do matter 2. Glycan ligation reactions in the periplasmic space 3. Synthesis of bioactive lipid A and analogues 4. Synthesis of lipopolysaccharide core fragments 5. Synthesis of oligosaccharides related to potential bioterrorist pathogens 6. Synthetic teichoic acid chemistry for vaccine applications 7. NMR characterization of bacterial glycans and glycoconjugate vaccines
II. Synthetic carbohydrate-based vaccines: present and future 8. Glycoconjugate vaccines, production and characterization 9. Antifungal glycoconjugate vaccines 10. Site-selective conjugation chemistry for synthetic glycoconjugate vaccine development 11. Glyconanoparticles as versatile platforms for vaccine development: A mini review
Synthetic organic chemists, as well as conjugation and protein chemists, immunologists, and microbiologists, in academia as well as industry
Bjørn E. Christensen holds a Dr. philos. degree in biotechnology from NTNU - Norwegian University of Science and Technology, Norway, where he also had a career as research scientist until 2002 when he became a full professor. His research field is polysaccharide engineering and includes studies of macromolecular characterisation and structure-function relationships in among other alginates, chitosans, pectins, xanthan and ß-1,3-glucans. He has also been visiting scientist/professor at Montana State University, USA (1985), Osaka Prefecture University, Japan (2009), Cermav-CNRS Grenoble, France (2010) and University of Bordeaux, France (2016).
Full professor, former director of the Institute of Chemistry and head of the Department of Organic Chemistry of the University of Debrecen, Hungary. Serves as an editorial board member for Carbohydrate Research, and as guest editor for special issues of Carbohydrate Research, Mini-Reviews in Medicinal Chemsitry, Molecules, Topics in Heterocyclic Chemistry. Research interests include synthetic carbohydrate chemistry directed to C-glycosyl compounds, anomeric-spirocycles, glycals, exo-glycals and their derivat
- Highlights important features of bacterial glycoproteins
- Illustrates modern chemical synthesis and structural analysis of bacterial glycans
- Demonstrates the importance of carbohydrate chemistry for the synthesis of lipopolysaccharides and teichoic acid
- Covers recent findings on glycan ligation
- Gives an overview of the most recent developments on carbohydrate-based vaccines