Animal Models of Neurotrauma, 1st ed. 2019
Neuromethods Series, Vol. 149

Coordinators: Risling Mårten, Davidsson Johan

Language: English

Approximative price 158.24 €

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302 p. · 17.8x25.4 cm · Hardback
This volume looks into the need for a variety of experimental models for research on traumatic brain injury (TBI) and peripheral nervous system. It also describes a number of experimental models, such as mechanical devices, that have been developed to model neurotrauma in animal experiments. The overall aim of this book is to explore the variety of models and how they are used in current research. The chapters in this book are organized in four sections and talk about animal models for TBI; animal models for spinal cord or nerve injury; and translational aspects, secondary injuries, in vitro studies, and evaluation of large data sets. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Cutting-edge and comprehensive, Animal Models of Neurotrauma is a valuable resource for researchers interested in expanding their knowledge and research in this developing field.

​Series Preface...
Preface...
Table of Contents...
Contributing Authors....

Part I Animal Models for Traumatic Brain Injury

1. The Fluid Percussion Injury Rodent Model in Preclinical Research on Traumatic Brain Injury
Fredrik Clausen, Lars Hillered, and Niklas Marklund

2. Focal and Restricted Traumatic Injury Models in the Rodent Brain—Limitations, Possibilities, and Challenges
Jesper Mogensen and Hana Malá

3. A Model for Research on Penetrating Traumatic Brain Injuries
Johan Davidsson and Mårten Risling

4. A Sagittal Plane Rotational Injury Rodent Model for Research on Traumatic Brain Injuries
Johan Davidsson and Mårten Risling

5. Experimental Models of Blast-Induced Neurotrauma
Pamela Boon Li Pun and Jia Lu

6. Utilization of Shock Tubes in Blast Injury Research
Ibolja Cernak

7. Introduction to Blast in the Context of Blast Induced TBI
Mat Philippens and Simon Ouellet

8. The Clemedson Blast Tube
Johan Davidsson, Ulf Arborelius, Lars-Gunnar Ohlsson, Lizan Kawa, Kian Chye NG, Jia Lu, and Mårten Risling

Part II Animal Models for Spinal Cord or Nerve Injury

9. Traumatic Peripheral Nerve Injuries – Experimental Models for Repair and Reconstruction
Lars B. Dahlin, Lena Stenberg, Ulrica Englund Johansson, and Fredrik Johansson

10. CNS Regeneration in Nerve Grafts - Practical Aspects of Complete Thoracic Spinal Cord Injury in Rodents
Arvid Frostell, Eric Peter Thelin, Per Mattsson, and Mikael Svensson

11. Experimental Nerve Plexus Root Avulsion and Spinal Cord Implantation
Thomas Carlstedt and Mårten Risling

12. Surgical Replantation of Avulsed Lumbosacral Ventral Roots and Urodynamic Studies in a Rhesus Macaque (Macaca mulatta) Model of Cauda Equina/Conus Medullaris Injury and Repair
Jaime H. Nieto, Huiyi H. Chang, Marcus Ohlsson, Una Lee, J. Pablo Villablanca, Kari L. Christe, and Leif A. Havton

Part III Translational Aspects, Secondary Injuries, In Vitro Studies or Evaluation of Large Data Sets

13. Secondary Insults in Experimental Traumatic Brain Injury – The Addition of Hypoxia
Caroline Lindblad and Eric P. Thelin

14. A Translational Model of Traumatic Brain Injury: Sheep Impact Acceleration Robert Vink

15. In Vitro Trauma – Description of a Cavitation Inducing Injury Model
Mattias. K. Sköld and Anders Sondén

16. Clinically Relevant Outcome Measures for Experimental Traumatic Brain Injury (TBI) Studies
Denes V. Agoston, Jesse McCullogh, Roxanne Aniceto, Alaa Kamnaksh, David K. Wright, and Sandy R. Shultz

Part IV Conclusion 

17. Concluding Remarks
Johan Davidsson and Mårten Risling