Injury Models of the Central Nervous System, Softcover reprint of the original 1st ed. 2016
Methods and Protocols
Methods in Molecular Biology Series, Vol. 1462

Language: English

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Injury Models of the Central Nervous System
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Approximative price 158.24 €

In Print (Delivery period: 15 days).

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Injury Models of the Central Nervous System
Publication date:
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This volume discusses experimental brain injury models that contain valuable information carefully chosen to widen the researchers? horizon about neurotrauma. Injury Models of Central Nervous System: Methods and Protocols contains relevant experimental design approaches that have been adapted and made ready for application in laboratory settings. For easier navigation, the chapters are categorized into 6 parts: Introduction, General Consideration in Using Animal Laboratory in CNS Injury Research, Classical TBI Models and Their Link with Pathophysiological Features of CBS Injury ? Models, Special Topics in CNS Trauma: Comorbid Conditions in CNS Injury, Outcome Measures in Brain Injury Models, and Future Directions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Practical and thorough, Injury Models of Central Nervous Systems: Methods and Protocols, is a very useful reference towards the progress of this discipline.

 

Part I Introduction

1.  The History and Evolution of Experimental Traumatic Brain Injury Models
John Povlishock


Part II. General Consideration in Using Animal Laboratory in CNS Injury Research

2. Clinical Traumatic Brain Injury in the Preclinical Setting
Justin Berkner, Rebekah Mannix, and Jianhua Qiu

3. Rodent Models of Traumatic Brain Injury: Methods and Challenges
Niklas Marklund

4. Traumatic Brain Injury Models in Animals
Elham Rostami

5. Systematic Review of Traumatic Brain Injury Animal Models
Helen W. Phipps

6. Methods of Drug Delivery in Neurotrauma
Ying Deng-Bryant, Ryan Readnower, Lai Yee Leung, Frank Tortella, and Deborah Shear

7. Bridging the Gap of Standardized Animals Models for Blast Neurotrauma:  Methodology for Appropriate Experimental Testing
Pamela J. VandeVord, Alessandra Dal Cengio Leonardi, and David Ritzel

8. Cellular Mechanisms and Behavioral Outcomes in Blast-Induced Neurotrauma: Comparing Experimental Set-Ups
Zachary S. Bailey, William Brad Hubbard, and Pamela J. VandeVord

9. Application of Systems Biology to Neuroproteomics: The Path to Enhanced Theranostics for Traumatic Brain Injury
Zaynab Jaber, Patrick Aouad, Mohamad Al Medawar, Hisham Bahmad, Hussein Abou Abbass, and Firas Kobeissy

10.  Role of Systems Biology in Brain Injury Biomarker Discovery: A Neuroproteomic Application
Zaynab Jaber, Patrick Aouad, Mohamad Al Medawar, Hisham Bahmad, Hussein Abou Abbass, Hiba Ghandour, Stefania Mondello, and Firas Kobeissy

Part III  Classical TBI Models and Their Link with Pathophysiological Features of CNS Injury – Models

11. The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol
Nicole Osier and C. Edward Dixon

12. Weight Drop Models in Traumatic Brain Injury
Brian T. Kalish and Michael J. Whalen

13. Midline (Central) Fluid Percussion Model of Traumatic Brain Injury
Rachel K. Rowe, Daniel R. Griffiths, and Jonathan Lifshitz

14. Lateral (Parasagittal) Fluid Percussion Model of Brain Injury
Ken C. Van and Bruce G. Lyeth

15. Impact Acceleration Model of Diffuse Traumatic Brain Injury
Sarah C. Hellewell, Jenna M. Ziebell, Jonathan Lifshitz, and M. Cristina Morganti-Kossmann

16. Experimental Models for Neurotrauma Research
Johan Davidsson and Mårten Risling

<17.  A Porcine Model of Traumatic Brain Injury via Head Rotational Acceleration
D. Kacy Cullen, James P. Harris, Kevin D. Browne, John A. Wolf, John E. Duda, David F. Meaney, Susan S. Margulies, and Douglas H. Smith

18. Pediatric Rodent Models of Traumatic Brain Injury
Bridgette D. Semple, Jaclyn Carlson, and Linda J. Noble-Haeusslein

19. Modeling Pediatric Brain Trauma: Piglet Model of Controlled Cortical Impact
Jennifer C. Munoz Paraja, Kristen Keeley, Ann-Christine Duhaime, and Carter P. Dodge

20. Thromboembolic Model of Cerebral Ischemia and Reperfusion in Mice
Ali Alawieh, Wenxue Wang, Aarti Narang, and Stephen Tomlinson

21. Animal Stroke Model: Ischemia/Reperfusion and Intracerebral Hemorrhage
Changhong Ren, Christopher Sy, Jinhuan Gao, Yuchuan Ding, and Xunming Ji
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22. Combined Neurotrauma Models: Experimental Models Combining Traumatic Brain Injury and Secondary Insults
Dennis W. Simon, Vincent M. Vagni, Patrick M. Kochanek, and Robert S. B. Clark

23.  Microdialysis as Clinical Evaluation of Therapeutic Hypothermia in Rat Subdural Hematoma Model
Shoji Yokobori, Markus S. Spurlock, Stephanie W. Lee, Shyam Gajavelli, and Ross M. Bullock

24.  Repetitive Transcranial Magnetic Stimulation as a Novel Therapy in Animal Models of Traumatic Brain Injury
Thangavelu Soundara Rajan, Salvatore Cuzzocrea, Daniele Bruschetta, and Angelo Quartarone

25. Experimental Models Combining TBI, Hemorrhagic Shock, and Hypoxemia
Lai Yee Leung, Ying Deng-Bryant, Deborah Shear, and Frank Tortella

26. Experimental Models Combining Traumatic Brain Injury and Hypoxia
Eric P. Thelin

27. Animal Models of Post-Traumatic Seizures and Epilepsy
Alexander V. Glushakov, Olena Y. Glushakova, Sylvain Doré, Paul R. Carney, and Ronald L. Hayes

28. Closed-Head TBI Model of Multiple-Morbidity
Floyd J. Thompson, Jiamei Hou, and Prodip K. Bose

Part V  Outcome Measures in Brain Injury Models

29.  Cognitive Evaluation Using Morris Water Maze in Neurotrauma
Ying Deng-Bryant, Lai Yee Leung, Krista Caudle, Frank Tortella, and Deborah Shear

30.  Assessment of Cognitive Function in the Water Maze Task: Maximizing Data Collection and Analysis in Animal Models of Brain Injury
Mark D. Whiting and Olga N. Kokiko-Cochran

31.  Detecting Behavioral Deficits Post Traumatic Brain Injury in RatsHibah O. Awwad

32.  Advanced and High Throughput Method for Mitochondrial Bioenergetics Evaluation in Neurotrauma
Jignesh D. Pandya, Patrick G. Sullivan, Lai Yee Leung, Frank C. Tortella, Deborah A. Shear, and Ying Deng-Bryant

33.  Determination of Vascular Reactivity of Middle Cerebral Arteries from Stroke and Spinal Cord Injury Animal Models Using Pressure Myography
Mohammad A. Anwar and Ali H. Eid

34.  Assessment of Basilar Artery Reactivity in Stroke and Subarachnoid Hemorrhage Using Wire Myograph
Crystal M. Ghantous, Zeina Azrak, Farah Abdel Rahman, Hana A. Itani, and Asad Zeidan

35.  Magnetic Resonance Imaging in Experimental Traumatic Brain Injury
Qiang Shen, Lora Tally Watts, Wei Li, and Timothy Q. Duong

36.  A Simplified Workflow for Protein Quantitation of Rat Brain Tissues Using Label-Free Proteomics and Spectral Counting
Angela M. Boutté, Shonnette F. Grant, and Jitendra R. Dave

37.  Phenotypic Screening of Small-Molecule Inhibitors: Implications for Therapeutic Discovery and Drug Target Development in Traumatic Brain Injury
Hassan Al-Ali, Vance P. Lemmon, and John L. Bixby

38.  Postnatal Neural Stem Cells in Treating Traumatic Brain Injury
Hussein Gazalah, Sarah Mantash, Naify Ramadan, Sawsan Al Lafi, Sally El Sitt, Hala Darwish, Hassan Azari, Lama Fawaz, Noël Ghanem, Kazem Zibara, Rose-Mary Boustany, Firas Kobeissy, and Jihane Soueid

39.  A Novel Biopsy Method for Isolating Neural Stem Cells from the Subventricular Zone of the Adult Rat Brain for Autologous Transplantation in CNS Injuries
Hadi Aligholi, Gholamreza Hassanzadeh, Ali Gorji, and Hassan Azari

Part VI Future Directions

40.  Challenging the Paradigms of Experimental TBI Models: From Preclinical to Clinical Practice
Frank Tortella
 

Includes cutting-edge methods and protocols

Provides step-by-step detail essential for reproducible results

Contains key notes and implementation advice from experts

Includes supplementary material: sn.pub/extras