Biochemical Pharmacology as an Approach to Gastrointestinal Disorders, Softcover reprint of the original 1st ed. 1997
Basic Science to Clinical Perspectives (1996)

Preface. Introduction : Advances in the Biochemical - Pharmacology of Gastrointestinal (GI) Functions as a Basis for - Understanding GI Disorders, K.D. Rainsford. I. - Gastrointestinal Secretory and Excretory Functions. II. - Gastrointestinal Motility. III.--IV. - Biochemical--Pharmacological Mechanisms in Neural and Hormonal - Normal and Pathological Reactions Involved in GI Functions. V. - GI Mucosal Injury and Protection. VI. Molecular Mechanisms of Premalignant and Malignant Diseases in GI Tract. VII. Use of Isolated Cells and Cell Cultures in Biochemical Pharmacological Studies to Approach GI Diseases. Index.

Introduction: Advances in the biochemical pharmacology of gastrointestinal (GI) functions as an approach to understanding GI disorders.- I. Gastrointestinal Secretory and Excretory Functions.- Possible compensation in epidermal growth factor production by saliva in rat.- Regulatory mechanism of acid secretion in rat stomach after damage — role of nitric oxide, histamine and sensory neurons.- Secretory pathways in histamine-containing enterochromaffin-like cells of rat stomach.- Nitric oxide as a modulator of fluid absorption in rat jejunum in vivo.- Mechanism of cholera.- Critical evaluation of acinar, ductal, vascular and intestinal intraluminal factors influencing pancreatic cytoprotection.- Peptide receptor antagonists and monoclonal antibodies raised against peptides: tools to study physiological regulation of pancreatic function.- Mechanisms and regulation of Cl- secretion in the large intestine: studies with the rat distal colon.- II. Gastrointestinal Motility.- Prostaglandin E2: actions on the circular and longitudinal contractions of the canine colon.- Gastric motor effects of endothelins in the lower brainstem of the rat.- Effects of erythromycin on the propulsive motility of upper gastrointestinal tract in rats.- Bicuculline blocks the inhibitory effects of substance P but not vasoactive intestinal polypeptide on gastric motor function in the nucleus raphe obscurus of the rat.- Pathological basis and clinical aspects of oesophageal motor disorders.- III–IV. Biochemical—Pharmacological Mechanisms in Neural and Hormonal Normal and Pathological Reactions Involved in GI Functions.- Distribution of muscarinic receptor mRNAs in the stomach of normal or immobilized rats.- Changes of sensory neuropeptides in experimental gastrointestinal diseases.- V. GI MucosalInjury and Protection.- Biochemical energetical backgrounds and their regulation in the gastric corpus mucosa in patients with different gastric secretory responses.- Oxidative stress and its prevention in toxic liver lesions. An overview.- The effect of drugs on liver function and biliary secretion.- Alteration of microvascular regeneration and permeability during acetic acid-induced gastric ulcer healing: effect of basic fibroblast growth factor.- Modulation of gastric wound repair by hepatocyte growth factor and basic fibroblast growth factor.- The effect of resiniferatoxin on experimental gastric ulcer in rats.- AIDS treatment and the heat shock protein level in the gastrointestinal tract.- ELISA and Western blot studies with basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) in experimental duodenal ulceration and healing.- Biological oxidants as intestinal secretagogues.- A new uniform biochemical explanation for the development and location of ‘genuine’ gastric, duodenal and jejunal ulcers in patients.- VI. Molecular Mechanisms of Premalignant and Malignant Diseases in GI Tract.- Current problems and results of tumour immunology: diagnostic and therapeutic relevance of tumour-associated antigens.- VII. Use of Isolated Cells and Cell Cultures in Biochemical Pharmacological Studies to Approach GI Diseases.- Does omeprazole-induced hypergastrinaemia contribute to the enhanced healing of acetic acid-induced gastric ulcers in rats?.- Modification of pathobiological events by potential hepatopharmacological agents.- Organoprotection and cytoprotection of histamine differ in rats.- Comparative viability studies on isolated gastric mucosal mixed cells and hepatoma and myeloma cell lines with ethanol, indomethacin and their combination.

The Gastrointestinal Section of the International Union of Pharmacology (IUPHAR) was established in 1994 in Montreal, Canada. The establishment of the GI Section recognizes the international progress of gastrointestinal pharmacology, including basic and human studies. The Gastrointestinal Section of IUPHAR organized the first symposium, Biochemical Pharmacology as an Approach to Gastrointestinal Diseases: from Basic Science to Clinical Perspectives, on 10--12 October, 1995, in Pecs, Hungary. The main topics were: The presented papers are published in this book.