DNA Repair

DNA Repair, Volume 115, the latest release in the Advances in Protein Chemistry and Structural Biology series, provides an overview of current developments in mechanisms underlying DNA repair, their involvement in maintaining chromatin repair, the balance between chromosome breaks repair pathways, tumorigenesis, immune signaling and infection-induced inflammation. Specific chapters cover the Structure and function of the multi-subunit TFIIH with insights into nucleotide excision repair, Chromatin repair: how DNA packaging controls double-strand break repair, Controlling the balance between chromosome breaks repair pathways, The targeting of DNA repair pathways in the era of precision oncology, and much more.

1. DNA repair by photolyasesIbrahim Halil Kavakli, Nuri Ozturk and Seref Gul2. TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair Olga Kolesnikova, Laura Radu, and Arnaud Poterszman3. Chromatin control in double strand break repairAnastas Gospodinov and Iva Ugrinova4. Controlling the balance between chromosome break repair pathwaysSonia Jimeno, Fernando Mejías-Navarro, Rosario Prados-Carvajal and Pablo Huertas5. Targeting DNA repair in precision medicineReena Beggs and Eddy S. Yang6. Replication stress: Driver and therapeutic target in genomically instable cancersPepijn M. Schoonen, Sergi Guerrero Llobet and Marcel A.T.M. van Vugt7. Claspin: From replication stress and DNA damage responses to cancer therapyDiana Azenha, Maria Celeste Lopes and Teresa C. Martins8. cAMP-mediated regulation of melanocyte genomic instability: A melanoma-preventive strategyNathaniel C. Holcomb, Robert-Marlo Bautista, Stuart G. Jarrett, Madeline Krentz Gober, Katharine M. Carter and John A. D’Orazio9. Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signalingShibani Mukherjee, Salim Abdisalaam, Souparno Bhattacharya, Kalayarasan Srinivasan, Debapriya Sinha and Aroumougame Asaithamby10. Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approachD. Thirumal Kumar, B. Susmita, E. Judith, J. Priyadharshini Christy, C. George Priya Doss and Hatem Zayed11. A computational model to predict the structural and functional consequences of missense mutations in O⁶-methylguanine DNA methyltransferaseThirumal Kumar D., Enid Mendonca, J. Priyadharshini Christy, C. George Priya Doss and Hatem Zayed

This volume would be of considerable interest to a very wide audience - protein chemists, biochemists, molecular biologists, cell biologists, immunologists, neuroscientists, structural biologists, medical doctors, pharmacologists, computational biochemists and other researchers working in this field. Articles published here would also be of a great benefit to medical, biology and pharmacology students specializing in this field.

• Describes advances in our understanding on DNA repair mechanisms and the involvement of their dysregulation in promoting diseases
• Presents data that is targeted to a very wide audience of specialists, researchers and students
• Contains timely chapters written by well-renowned authorities in their field
• Provides targeted information that is well supported by a number of high-quality illustrations, figures and tables