Food Allergy and Intolerance (2^nd Ed.)

In the 15 years since the first edition of Food Allergy and Intolerance was published, the subject has become the focus of intense public interest. Not only are more people aware of the phenomena involved, but new evidence and practices are constantly being introduced, and there has been an unprecedented growth of the field. The second edition encompasses the rigour and depth of the first, whilst incorporating all the changes required to produce the definitive guide to the subject for all those involved. The symptoms of a food allergy or intolerance impact not only on all allergists, immunologists, nutritionists, gastroenterologists and pathologists, but on doctors of respiratory medicine, dermatologists, general practitioners, pharmacologists and all those in environmental medicine.

Preface to the second edition Preface to the first edition Why do we eat? Morrell Draper Part 1.- BASIC MECHANISMS Section A - NORMAL STRUCTURE AND FUNCTION. The structure and organisation of lymphoid tissue in the gut T McDonald. Basic functions of the gut J Sanderson and CN Mallinson. Adhesion molecules and circulation and differentiation of lymphocytes in GALT and mammary glands JM Phillips-Quagliata. Innnervation of lymphoid tissue and functional consequences of neurotransmitter and neuropeptide release J Santos, J Bienenstock and M Perdue Section B - SPECIALIZED CELLS AND SECRETIONS OF THE GUT. Macrophages DE Bockman. Intestinal mast cells GR Stenton and AD Befus. The mucosal T cell J Strid and S Strobel. Natural killer cells and aspects of intestinal immunity S Strobel and J Strid. The mucosal B cell and its function P Brandtzaeg. The Enterocytes R Mirakian and IR Sanderson. Mucosal antibodies and induction of the immunoglobulin A responses J Mestecky and MW Russell. The composition and function of the mucus barrier in the gastrointestinal tract AP Corfield, R Longman, T Shirazi, S Hicks, N Myerscough and C Proberts Section C - ANTIGEN HANDLING AND IMMUNE RESPONSE. Role of mucosal barrier in antigen handling by the gut WA Walker. Immunodeficiency and antigen exclusion C Cunningham-Rundles. Causes and consequences of altered gut permeability 1.Bjarnason and IS Menzies. Oral tolerance: probable mechanisms and possible therapeutic applications S Challacombe and C Czerkinsky Section D - MECHANISMS OF DAMAGE. Intestinal pathogenetic correlates of clinical food allergic disorders M Marsh. Animal models of food sensitivity CR Stokes, M Bailey and PW Bland. Immunologically mediated damage of the gut WE Fickling and DAF Robertson. Non-immune damage of the gut WE Fickling and DAF Robertson. Mediators in food allergy CH Little. Diet and the metabolism of intestinal bacteria GT Macfarlane and JH Cummings. Infections of the gastrointestinal tract and food intolerance JO Hunter. Is there an allergic and fermentive gut condition, and does it relate to Candida? K Eaton. Enzyme deficiency T Cox. Nutritional effects on human immune functions DA Hughes Part 2.- FOOD COMPONENTS AND THEIR REACTIONS Section A - EXAMPLES OF FOODS AS ALLERGENS. Foods as allergens SL Taylor and SL Hefle. Acute allergic reactions to foods and cross reactivity between foods AW Frankland and RSH Pumphrey. Fish allergy and the codfish allergen model S Elsayed. Cow's milk and breast milk JW Gerrard Section B - NON-ALLERGENIC EFFECTS OF FOOD. Pharmacological actions of food and drink TJ Maher. Food chemicals and their elimination RH Waring. Exorphins and other biologically active peptides derived from diet MLG Gardner. Dietary lectins and disease DLJ Freed Part 3.- END-ORGAN EFFECT Section A - RESPIRATORY TRACT. Rhinitis, secretory otitis media and sinus disease caused by food allergy Z Pelikan. Food-induced asthma JG Ayres and JC Baker. Alveolitis DJ Hendrick and AG Bird Section B - GASTROINTESTINAL TRACT. Intestinal manifestations of food allergy and intolerance SC Bischoff and JH Mayer. Oral manifestations of food allergy and intolerance D Wray. Gluten toxicity in coeliac disease PJ Ciclitira and HJ Ellis. Irritable bowel syndrome, Crohn's disease and ulcerative colitis KLE Dear and JO Hunter. Paediatric gastrointestinal food-allergic disease RPK Ford and J Walker-Smith Section C - SKIN. Atopic eczema N Kapur and MHA Rustin. Food intolerance in urticaria and angio-oedema and urticarial vasculitis M Greaves. Skin contact reactions to foods and spices L Kanerva. Dermatitis herpetiformis J Leonard and L Fry Section D - CENTRAL NERVOUS SYSTEM. Effects of food allergy on the central nervous system IR Bell. Psychological aspects of food intolerance DS King. The psychologization of illness EM Goudsmit. Food allergy and the central nervous system in childhood J Egger. The hyperkinetic syndrome J Egger. The potential role of trace elements in child hyperkinetic disorders NI Ward. Food addiction and criminal behaviour SJ Schoenthaler and ID Bier Section E - RHEUMATOLOGY. Joints and arthritic disease LG Darlington. Ankylosing spondylitis and diet A Ebringer and C Wilson Section F - OTHER ORGANS. Food sensitivity: the kidney and bladder D Sandberg. Cardiovascular disease in response to foods and chemicals WJ Rea and GH Ross Part 4.- CLINICAL DIAGNOSIS OF FOOD ALLERGY AND INTOLERANCE. Historical perspectives: clinical presentations, pathogenesis and diagnosis of food hypersensitivities AS Goldman, AG Kantak and AJH Pong. Elimination diets as a diagnostic tool MJ Radcliffe. Food allergy/sensitivity diagnosed by skin testing FJ Waickman. Laboratory diagnosis of food intolerance DLJ Freed and FJ Waickman. Diagnosis of gastrointestinal food allergic disease in childhood AD Phillips and J Walker-Smith. Diagnosis of gastrointestinal food allergic disease in adults MMC McMullan and JO Hunter. Non-immunological adverse reactions to food G Kanny and DA Moneret-Vautrin. Hyperventilation and allergy LM McEwen and S Widmer Part 5.- TREATMENT OF FOOD ALLERGY. Practical application and hazards of dietary management in food intolerance G Pollard. Drug treatment of food allergy and intolerance LJF Youlten. The contribution of an environmental unit to the diagnosis and management of chronic symptoms DJ Maberly and HM Anthony. Enzyme-potentiated desensitisation LM McEwen. Prevention of food allergy in infants and children B Björkstén Index

Immunologists and Allergists, Gastroenterologists, Respiratory Physicians, General Physicians, Nutritionists, Environmental Medics and trainees in all these areas.