Description
Biocatalysis in the Pharmaceutical and Biotechnology Industries
Coordinator: Patel Ramesh N.
Language: EnglishSubjects for Biocatalysis in the Pharmaceutical and Biotechnology...:
Keywords
Sim Ilar; Red Uction; Substr Ate; Nitrile Hydratase; Hydroxynitrile Lyases; Amine Oxidases; DNA Shuffling; High Throughput Screening; Acyl Donor; Kinetic Resolution; Chiral Amine; Chemoenzymatic Synthesis; Candida Antarctica Lipase; Lipase PS-30; Isopropenyl Acetate; Struc Ture; Nitrilase Activity; Biocatalytic Reduction; Enzymatic Resolution; Lipase AK; Racem Ic; Regener Ation; Acyloin Condensation; Evo Lution; Chiral Alcohols
Publication date: 01-2020
· 17.8x25.4 cm · Paperback
Publication date: 09-2006
880 p. · 17.8x25.4 cm · Hardback
Description
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Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications.
Written by internationally recognized scientists in biocatalysis, the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction?including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C?C, C?N, C?O bonds formation. Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening.
Focusing on industrial applications, the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization, reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases the practical advantages and methodologies for using biocatalysts to develop and produce chiral pharmaceuticals and fine chemicals.
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